Phenotypes associated with this allele

• Allele Symbol: Prdm2⁺
• Allele Name: wild type
• Allele ID: MGI:2433926
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Prdm2^tm1Shg/Prdm2^+	involves: 129S2/SvPas * C57BL/6	MGI:3041265

Genotype
MGI:3041265

ht1

• Allelic Composition: Prdm2^tm1Shg/Prdm2⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:71406 )

• obvious decline in survival between 450 and 600 days of age, whereas wild-type controls had no such decline

neoplasm

increased tumor incidence ( J:71406 )

• at 20 months of age 49% of mice examined had tumors, incidence in wild-type controls was 30%

• incidence of tumors in multiple organs was 19% vs. 4% in wild-type controls

increased pituitary adenoma incidence ( J:71406 )

• at 20 months, in 2% of mice examined vs. 0% in wild-type controls

increased lymphoma incidence ( J:71406 )

• at 20 months, 2% of mice examined had fibrosing large cell lymphoma vs. 0% in wild-type controls

increased B cell derived lymphoma incidence ( J:71406 )

• at 20 months of age 19% of mice examined had diffuse large B-cell lymphoma vs. 0% in wild-type controls

increased lung adenocarcinoma incidence ( J:71406 )

• at 20 months, in 21% of mice examined vs. 17% in wild-type controls

increased hemangiosarcoma incidence ( J:71406 )

• at 20 months, 2% of mice examined had hemangiosarcoma vs. 0% in wild-type controls

nervous system

increased pituitary adenoma incidence ( J:71406 )

• at 20 months, in 2% of mice examined vs. 0% in wild-type controls

endocrine/exocrine glands

increased pituitary adenoma incidence ( J:71406 )

• at 20 months, in 2% of mice examined vs. 0% in wild-type controls

respiratory system

increased lung adenocarcinoma incidence ( J:71406 )

• at 20 months, in 21% of mice examined vs. 17% in wild-type controls