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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gjb6+
wild type
MGI:2433853
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Gjb6tm1.1Fama/Gjb6+ involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:4848187
ht2
 		Gjb6tm1Kwi/Gjb6+ involves: 129P2/OlaHsd * C57BL/6J MGI:3043968


Genotype
MGI:4848187
ht1
Allelic
Composition		 Gjb6tm1.1Fama/Gjb6+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjb6tm1.1Fama mutation (1 available); any Gjb6 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:166362 )
N
• unlike heterozygous human carriers, mice exhibit normal auditory brainstem responses




Genotype
MGI:3043968
ht2
Allelic
Composition		 Gjb6tm1Kwi/Gjb6+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjb6tm1Kwi mutation (1 available); any Gjb6 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system physiology ( J:89971 )
• acetylcholine levels in the ventral striatum are reduced and choline levels in the frontal cortex and neostriatal increased compared to wild-type mice

homeostasis/metabolism
decreased dopamine level ( J:89971 )
• dopamine and some dopamine metabolite levels are decreased in the amygdala and ventral striatum compared to wild-type mice




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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory