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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myl7+
wild type
MGI:2433804
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Myl7tm1(cre)Krc/Myl7+
Prkg1tm2Naw/Prkg1tm2Naw 		either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) MGI:2668843
cn2
 		Mapk14tm1Lex/Mapk14tm1Lex
Myl7tm1(cre)Krc/Myl7+ 		involves: 129S1/Sv * 129S5/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:3580021
cn3
 		Hcn2tm1Ldw/Hcn2tm2Ldw
Myl7tm1(cre)Krc/Myl7+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3623024


Genotype
MGI:2668843
cn1
Allelic
Composition		 Myl7tm1(cre)Krc/Myl7+
Prkg1tm2Naw/Prkg1tm2Naw
Genetic
Background		 either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl7tm1(cre)Krc mutation (0 available); any Myl7 mutation (7 available)
Prkg1tm2Naw mutation (0 available); any Prkg1 mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiac muscle contractility ( J:84611 )
• cGMP analogues reduce the force of contraction in cardiac muscle from adult controls but not from adult mutants

muscle
abnormal cardiac muscle contractility ( J:84611 )
• cGMP analogues reduce the force of contraction in cardiac muscle from adult controls but not from adult mutants




Genotype
MGI:3580021
cn2
Allelic
Composition		 Mapk14tm1Lex/Mapk14tm1Lex
Myl7tm1(cre)Krc/Myl7+
Genetic
Background		 involves: 129S1/Sv * 129S5/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk14tm1Lex mutation (1 available); any Mapk14 mutation (43 available)
Myl7tm1(cre)Krc mutation (0 available); any Myl7 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal myocardial fiber physiology ( J:98514 )
• homozygous mice that are heterozygous for Myl7 tm1(cre)Krc, in which cre mediated recombination is induced in cardiomyocytes, display increased mitosis in 4 day old and adult mice cardiomyocytes




Genotype
MGI:3623024
cn3
Allelic
Composition		 Hcn2tm1Ldw/Hcn2tm2Ldw
Myl7tm1(cre)Krc/Myl7+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcn2tm1Ldw mutation (0 available); any Hcn2 mutation (31 available)
Hcn2tm2Ldw mutation (0 available); any Hcn2 mutation (31 available)
Myl7tm1(cre)Krc mutation (0 available); any Myl7 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
irregular heartbeat ( J:81398 )
• variable intervals between heart beats
abnormal sinoatrial node conduction ( J:81398 )
• sinus dysrhythmia at rest but not during spontaneous activity
• variable intervals between successive heart beats
• regular P wave in a normal PR interval indicating synoatrial node dysfunction
• 30% reduced inward current of sinoatrial cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory