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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Notch4+
wild type
MGI:2433787
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Notch4tm1.1(cre/ERT2)Sat/Notch4+ C57BL/6-Notch4tm1.1(cre/ERT2)Sat MGI:5304927
ht2
 		Notch4tm1Grid/Notch4+ involves: 129S1/Sv * C57BL/6J MGI:5790676
ht3
 		Notch4tm1(KOMP)Vlcg/Notch4+ involves: C57BL/6NTac MGI:5790679


Genotype
MGI:5304927
ht1
Allelic
Composition		 Notch4tm1.1(cre/ERT2)Sat/Notch4+
Genetic
Background		 C57BL/6-Notch4tm1.1(cre/ERT2)Sat
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch4tm1.1(cre/ERT2)Sat mutation (0 available); any Notch4 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:179632 )
• heterozygotes are viable and fertile




Genotype
MGI:5790676
ht2
Allelic
Composition		 Notch4tm1Grid/Notch4+
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch4tm1Grid mutation (2 available); any Notch4 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:212472 )
• P5 retinas show a 18.0% reduction in the area covered by the vascular plexus relative to wild-type retinas
abnormal retina blood vessel morphology ( J:212472 )
• P5 retinas show a 16.9% reduction in total vessel length relative to wild-type retinas
• however, vessel length density (ratio of total vessel length to vascular area) and fractal dimension (a measure of tortuosity) remain normal

vision/eye
abnormal retina vasculature morphology ( J:212472 )
• P5 retinas show a 18.0% reduction in the area covered by the vascular plexus relative to wild-type retinas
abnormal retina blood vessel morphology ( J:212472 )
• P5 retinas show a 16.9% reduction in total vessel length relative to wild-type retinas
• however, vessel length density (ratio of total vessel length to vascular area) and fractal dimension (a measure of tortuosity) remain normal




Genotype
MGI:5790679
ht3
Allelic
Composition		 Notch4tm1(KOMP)Vlcg/Notch4+
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch4tm1(KOMP)Vlcg mutation (3 available); any Notch4 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:212472 )
• P5 retinas show a 10.9% reduction in the area covered by the vascular plexus relative to wild-type retinas
abnormal retina blood vessel morphology ( J:212472 )
• P5 retinas show a significant (9.7%) reduction in total vessel length relative to wild-type retinas
• however, vessel length density (ratio of total vessel length to vascular area) and fractal dimension (a measure of tortuosity) remain normal

vision/eye
abnormal retina vasculature morphology ( J:212472 )
• P5 retinas show a 10.9% reduction in the area covered by the vascular plexus relative to wild-type retinas
abnormal retina blood vessel morphology ( J:212472 )
• P5 retinas show a significant (9.7%) reduction in total vessel length relative to wild-type retinas
• however, vessel length density (ratio of total vessel length to vascular area) and fractal dimension (a measure of tortuosity) remain normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory