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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aff3+
wild type
MGI:2433733
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Aff3tm1a(EUCOMM)Wtsi/Aff3+ C57BL/6N-Aff3tm1a(EUCOMM)Wtsi/Wtsi MGI:5705951
ht2
 		Aff3em1Andg/Aff3+ involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1 MGI:7266717
ht3
 		Aff3em1Xen/Aff3+ involves: C57BL/6N MGI:7266690


Genotype
MGI:5705951
ht1
Allelic
Composition		 Aff3tm1a(EUCOMM)Wtsi/Aff3+
Genetic
Background		 C57BL/6N-Aff3tm1a(EUCOMM)Wtsi/Wtsi
Cell Lines EPD0242_2_E12
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aff3tm1a(EUCOMM)Wtsi mutation (1 available); any Aff3 mutation (50 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton




Genotype
MGI:7266717
ht2
Allelic
Composition		 Aff3em1Andg/Aff3+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aff3em1Andg mutation (0 available); any Aff3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality ( J:317476 )
• no heterozygous offspring are produced by high proportion chimeras suggesting prenatal lethality




Genotype
MGI:7266690
ht3
Allelic
Composition		 Aff3em1Xen/Aff3+
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aff3em1Xen mutation (0 available); any Aff3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality ( J:317476 )
• no heterozygous offspring are produced by chimeras suggesting prenatal lethality
• high proportion chimeras are also not viable




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory