Analysis Tools|
Allele Symbol Allele Name Allele ID |
Lama5+ wild type MGI:2433534 |
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| Summary |
4 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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IMPC - HAR
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IMPC - HAR
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E13.5, mutant mice fail to form a distinct single layer of dental epithelium unlike heterozygous controls
• at E14.5, mutant mice do not form an enamel knot structure and the size of the tooth germ is reduced compared to controls; the number of proliferating cells in the outer and inner epithelia and surrounding mesenchyme is reduced by 50% in mutant mice
• at E17.5, the inner dental epithelium is not polarized, forms an elongated shape and remains rounded in shape, in contrast to morphology in controls
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• at E13.5, mutant mice fail to form a distinct single layer of dental epithelium unlike heterozygous controls
• at E14.5, mutant mice do not form an enamel knot structure and the size of the tooth germ is reduced compared to controls; the number of proliferating cells in the outer and inner epithelia and surrounding mesenchyme is reduced by 50% in mutant mice
• at E17.5, the inner dental epithelium is not polarized, forms an elongated shape and remains rounded in shape, in contrast to morphology in controls
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• at E13.5, mutant mice fail to form a distinct single layer of dental epithelium unlike heterozygous controls
• at E14.5, mutant mice do not form an enamel knot structure and the size of the tooth germ is reduced compared to controls; the number of proliferating cells in the outer and inner epithelia and surrounding mesenchyme is reduced by 50% in mutant mice
• at E17.5, the inner dental epithelium is not polarized, forms an elongated shape and remains rounded in shape, in contrast to morphology in controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• normal kidney function at 22 weeks of age, as determined by plasma creatinine, urea and albumin levels
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| N |
• normal levels of plasma creatinine, urea and albumin levels at 6 months of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at E13.5, mutant mice fail to form a distinct single layer of dental epithelium unlike heterozygous controls
• at E14.5, mutant mice do not form an enamel knot structure and the size of the tooth germ is reduced compared to controls; the number of proliferating cells in the outer and inner epithelia and surrounding mesenchyme is reduced by 50% in mutant mice
• at E17.5, the inner dental epithelium is not polarized, forms an elongated shape and remains rounded in shape, in contrast to morphology in controls
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• at E13.5, mutant mice fail to form a distinct single layer of dental epithelium unlike heterozygous controls
• at E14.5, mutant mice do not form an enamel knot structure and the size of the tooth germ is reduced compared to controls; the number of proliferating cells in the outer and inner epithelia and surrounding mesenchyme is reduced by 50% in mutant mice
• at E17.5, the inner dental epithelium is not polarized, forms an elongated shape and remains rounded in shape, in contrast to morphology in controls
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• at E13.5, mutant mice fail to form a distinct single layer of dental epithelium unlike heterozygous controls
• at E14.5, mutant mice do not form an enamel knot structure and the size of the tooth germ is reduced compared to controls; the number of proliferating cells in the outer and inner epithelia and surrounding mesenchyme is reduced by 50% in mutant mice
• at E17.5, the inner dental epithelium is not polarized, forms an elongated shape and remains rounded in shape, in contrast to morphology in controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/24/2026 MGI 6.24 |
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