Phenotypes associated with this allele
Allelic
Composition |
Mcm2Gt(AB0178)Wtsi/Mcm2+
|
|
Genetic
Background |
involves: 129P2/OlaHsd * C3HeB/FeJ |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation
(0 available);
any
Mcm2 mutation
(49 available)
|
|
|
cellular
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
hematopoietic system
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation
(0 available);
any
Mcm2 mutation
(49 available)
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
Mcm4Gt(RRE056)Byg mutation
(0 available);
any
Mcm4 mutation
(42 available)
Mcm6Gt(YHD248)Byg mutation
(0 available);
any
Mcm6 mutation
(37 available)
Mcm7Gt(YTA285)Byg mutation
(0 available);
any
Mcm7 mutation
(45 available)
|
|
|
cellular
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
hematopoietic system
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation
(0 available);
any
Mcm2 mutation
(49 available)
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
|
|
|
cellular
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
hematopoietic system
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation
(0 available);
any
Mcm2 mutation
(49 available)
Mcm4Gt(RRE056)Byg mutation
(0 available);
any
Mcm4 mutation
(42 available)
|
|
|
cellular
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
hematopoietic system
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation
(0 available);
any
Mcm2 mutation
(49 available)
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
Mcm4Gt(RRE056)Byg mutation
(0 available);
any
Mcm4 mutation
(42 available)
|
|
|
cellular
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
hematopoietic system
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation
(0 available);
any
Mcm2 mutation
(49 available)
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
Mcm6Gt(YHD248)Byg mutation
(0 available);
any
Mcm6 mutation
(37 available)
|
|
|
cellular
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
hematopoietic system
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation
(0 available);
any
Mcm2 mutation
(49 available)
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
Mcm6Gt(YHD248)Byg mutation
(0 available);
any
Mcm6 mutation
(37 available)
Mcm7Gt(YTA285)Byg mutation
(0 available);
any
Mcm7 mutation
(45 available)
|
|
|
cellular
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
hematopoietic system
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation
(0 available);
any
Mcm2 mutation
(49 available)
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
Mcm4Gt(RRE056)Byg mutation
(0 available);
any
Mcm4 mutation
(42 available)
Mcm6Gt(YHD248)Byg mutation
(0 available);
any
Mcm6 mutation
(37 available)
|
|
|
cellular
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
hematopoietic system
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation
(0 available);
any
Mcm2 mutation
(49 available)
Mcm4Gt(RRE056)Byg mutation
(0 available);
any
Mcm4 mutation
(42 available)
Mcm6Gt(YHD248)Byg mutation
(0 available);
any
Mcm6 mutation
(37 available)
|
|
|
cellular
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
hematopoietic system
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation
(0 available);
any
Mcm2 mutation
(49 available)
Mcm4chaos3 mutation
(1 available);
any
Mcm4 mutation
(42 available)
|
|
|
mortality/aging
|
|
• mice begin to die at 2 months and all mice die by 7 months of age
|
|
|
• fewer than expected mice are produced (no time point given)
|
neoplasm
|
|
• mice exhibit lymphomas/leukemias
• three-quarters of mice develop tumors by 18 months
|
hematopoietic system
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice and Mcm4chaos3 homozygotes
|
|
|
• mice exhibit an increase in the number of CD71+ (proliferating cells, reticulocytes, erythroid precursors) cells compared with Mcm4chaos3 homozygotes
|
cellular
|
|
• in mouse embryonic fibroblasts after 5 days in culture
|
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice and Mcm4chaos3 homozygotes
|
embryo
|
|
• mouse embryonic fibroblasts exhibit compromised ability to form induced pluripotent stem cells compared with Mcm4chaos3 homozygous cells
|
growth/size/body
endocrine/exocrine glands
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation
(0 available);
any
Mcm2 mutation
(49 available)
Mcm3Gt(RRR002)Byg mutation
(0 available);
any
Mcm3 mutation
(43 available)
Mcm4chaos3 mutation
(1 available);
any
Mcm4 mutation
(42 available)
|
|
|
mortality/aging
|
|
• lifespan is expanded compared to in Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 mice but all mice die by 12 months of age
|
|
|
• mortality observed in Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 mice is largely rescued
|
neoplasm
|
|
• onset of tumorigenesis (lymphoma, thymoma, bone tumors, and liver tumors) is delayed or eliminated compared with Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 mice
|
hematopoietic system
|
N |
• the ratio of CD71+ reticulocytes to total red blood cells is completely corrected compared to in Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 mice
|
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with Mcm4chaos3 homozygotes
|
cellular
|
|
• mouse embryonic fibroblast proliferation (MEFs) is partially rescued compared to in Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 MEFs
|
|
|
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with Mcm4chaos3 homozygotes
|
embryo
|
|
• mouse embryonic fibroblasts exhibit compromised ability to form induced pluripotent stem cells compared with Mcm4chaos3/Mcm4chaos3 cells but improved 2.5- to 10-fold compared with Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 cells
|
growth/size/body
|
N |
• body weight is rescued compared with Mcm2Gt(AB0178)Wtsi/Mcm2+ Mcm4chaos3/Mcm4chaos3 mice
|
Analysis Tools