Phenotypes associated with this allele

• Allele Symbol: Gclc⁺
• Allele Name: wild type
• Allele ID: MGI:2433520
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gclc^tm1Dwn/Gclc^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3836446
ht2	Gclc^tm1Mwl/Gclc^+	involves: 129S7/SvEvBrd * C57BL/6	MGI:3814418
cn3	Gclc^tm1c(EUCOMM)Wtsi/Gclc^+ Tg(Cryaa-cre)10Mlr/0	involves: 129S4/SvJaeSor * C57BL/6N * FVB/N	MGI:5475288

Genotype
MGI:3836446

ht1

• Allelic Composition: Gclc^tm1Dwn/Gclc⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

abnormal liver physiology ( J:66499 )

• hepatic GSH levels are about 20% lower compared to controls

• hepatic ascorbate levels are about 30% higher compared to controls

Genotype
MGI:3814418

ht2

• Allelic Composition: Gclc^tm1Mwl/Gclc⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:62177 )

• mice are show no obvious abnormalities and are fertile

Genotype
MGI:5475288

cn3

• Allelic Composition: Gclc^{tm1c(EUCOMM)Wtsi}/Gclc⁺; Tg(Cryaa-cre)10Mlr/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB/N
• Cell Lines: EPD0051_3_D07

cellular

oxidative stress ( J:194778 )

• mild increase in reactive oxygen species production as determined by GSSG/GSH ratio