All Phenotypes Gpc3<+> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gpc3⁺
wild type
MGI:2433496

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gpc3^tm1Fil/Gpc3⁺	B6.Cg-Gpc3^tm1Fil	MGI:3530366
ht2	Gpc3^tm1Arge/Gpc3⁺	either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)	MGI:3629781
ht3	Gpc3^Gt(Ex136)Byg/Gpc3⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3849593
ht4	Gpc3^tm1Snd/Gpc3⁺	involves: 129X1/SvJ * C57BL/6	MGI:3849591
cx5	Gpc3^tm1Arge/Gpc3⁺ Igf2^tm1Rob/Igf2⁺	involves: 129S/SvEv * 129S1/Sv * C57BL/6J	MGI:3629782

Allelic Composition	Gpc3^tm1Fil/Gpc3⁺
Genetic Background	B6.Cg-Gpc3^tm1Fil

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3^tm1Fil mutation (1 available); any Gpc3 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cystic and dysplastic kidneys in Gpc3^tm1Fil/Gpc3⁺ mice

renal/urinary system

kidney cyst ( J:73877 )

• from N4 on, some heterozygous females display cystic kidneys (also noted in a large proportion of mice from earlier backcrosses)

abnormal kidney development ( J:73877 )

• from N4 on, some heterozygous females display dysplastic kidneys (also noted in a large proportion of mice from earlier backcrosses)

• the degree of renal dysplasia varies from mouse to mouse

abnormal ureteric bud morphology ( J:73877 )

impaired branching involved in ureteric bud morphogenesis ( J:73877 )

growth/size/body

increased body weight ( J:73877 )

• heterozygotes display an intermediate size between hemizygous mutant males and wild-type controls at all time points

kidney cyst ( J:73877 )

• from N4 on, some heterozygous females display cystic kidneys (also noted in a large proportion of mice from earlier backcrosses)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Simpson-Golabi-Behmel syndrome type 1		DOID:0060248	OMIM:312870	J:73877

Allelic Composition	Gpc3^tm1Arge/Gpc3⁺
Genetic Background	either: (involves: 129S/SvEv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3^tm1Arge mutation (0 available); any Gpc3 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

white spotting ( J:75054 )

• 26% lack pigmentation in the feet and distal third of their tails

belly spot ( J:75054 )

• about 2% exhibit white belly spotting

integument

white spotting ( J:75054 )

• 26% lack pigmentation in the feet and distal third of their tails

belly spot ( J:75054 )

• about 2% exhibit white belly spotting

Allelic Composition	Gpc3^Gt(Ex136)Byg/Gpc3⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3^Gt(Ex136)Byg mutation (0 available); any Gpc3 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal ventral body wall morphology ( J:64330 )

• ventral wall closure defects with incomplete penetrance

• usually results in small to moderate umbilical hernias

kidney medulla cyst ( J:64330 )

• medullary cystic dysplasia

increased body size ( J:64330 )

• males are 30% larger than controls

• females show intermediate growth properties

renal/urinary system

abnormal kidney medulla morphology ( J:64330 )

• medullary cystic dysplasia

kidney medulla cyst ( J:64330 )

• medullary cystic dysplasia

skeleton

split xiphoid process ( J:64330 )

• bifurcated

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Simpson-Golabi-Behmel syndrome type 1		DOID:0060248	OMIM:312870	J:64330

Allelic Composition	Gpc3^tm1Snd/Gpc3⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3^tm1Snd mutation (0 available); any Gpc3 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal ventral body wall morphology ( J:64330 )

• ventral wall closure defects with incomplete penetrance

• usually results in small to moderate umbilical hernias

kidney cyst ( J:64330 )

• medullary cystic dysplasia

increased body size ( J:64330 )

• males are 30% larger than controls

• females show intermediate growth properties

renal/urinary system

kidney cyst ( J:64330 )

• medullary cystic dysplasia

abnormal kidney medulla morphology ( J:64330 )

• medullary cystic dysplasia

skeleton

split xiphoid process ( J:64330 )

• bifurcated

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Simpson-Golabi-Behmel syndrome type 1		DOID:0060248	OMIM:312870	J:64330

Allelic Composition	Gpc3^tm1Arge/Gpc3⁺ Igf2^tm1Rob/Igf2⁺
Genetic Background	involves: 129S/SvEv * 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpc3^tm1Arge mutation (0 available); any Gpc3 mutation (18 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

abnormal body size ( J:75054 )

• double mutants inheriting the mutant Igf2 allele paternally are larger than mice lacking Igf2

cellular

maternal imprinting ( J:75054 )

• defect is seen in double mutants that receive the Igf2 mutant allele from the father

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24