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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Erbb4+
wild type
MGI:2433277
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Erbb4tm1Grl/Erbb4+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3578334
ht2
 		Erbb4tm1.1(cre/ERT2)Aibs/Erbb4+ involves: C3H * C57BL/6 MGI:4429704


Genotype
MGI:3578334
ht1
Allelic
Composition		 Erbb4tm1Grl/Erbb4+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb4tm1Grl mutation (1 available); any Erbb4 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
hyperactivity ( J:81106 )
• animals are significantly more active than controls in an open field test, but less significantly than Nrg1 heterozygotes

nervous system
abnormal prepulse inhibition ( J:81106 )
• impairment was seen, but not as severely as in the Nrg1 heterozygous mice
• normal acoustic startle response was observed




Genotype
MGI:4429704
ht2
Allelic
Composition		 Erbb4tm1.1(cre/ERT2)Aibs/Erbb4+
Genetic
Background		 involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb4tm1.1(cre/ERT2)Aibs mutation (1 available); any Erbb4 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:155793 )
• animals are viable and fertile




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory