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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rela+
wild type
MGI:2433185
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Nfkb1tm1Bal/Nfkb1tm1Bal
Relatm1Bal/Rela+ 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:3799208


Genotype
MGI:3799208
cx1
Allelic
Composition		 Nfkb1tm1Bal/Nfkb1tm1Bal
Relatm1Bal/Rela+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1tm1Bal mutation (3 available); any Nfkb1 mutation (104 available)
Relatm1Bal mutation (1 available); any Rela mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
diarrhea ( J:67107 )
• severe
abnormal colon morphology ( J:67107 )
• mice exhibit colonic perforations and typhlocolitis
large intestinal inflammation ( J:67107 )
• mice exhibit typhlocolitis

immune system
large intestinal inflammation ( J:67107 )
• mice exhibit typhlocolitis
increased susceptibility to bacterial infection ( J:67107 )
• mice are more sensitive to typhlocolitis induced by H. hepaticus than wild-type mice with a more rapid onset of diarrhea, enlargement and thickening of the colon, thickening of the mucosa characterized by extensive ulcerations, elongated irregularly shaped glands and crypt abscesses, lamina propria fibrosis and infiltration granulation tissue, dilated lymphatics, and multifocal necrotizing vasculitis with thrombosis, and expanded submucosa and serosa with infiltration




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory