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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Xpc+
wild type
MGI:2433151
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Xpctm1Ecf/Xpc+ involves: 129 * SKH1 MGI:3710352
cx2
 		Ercc8tm1Jhjh/Ercc8tm1Jhjh
Xpctm1Ecf/Xpc+ 		involves: 129P2/OlaHsd * C57BL/6J MGI:2663268


Genotype
MGI:3710352
ht1
Allelic
Composition		 Xpctm1Ecf/Xpc+
Genetic
Background		 involves: 129 * SKH1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xpctm1Ecf mutation (1 available); any Xpc mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
increased sensitivity to skin irradiation ( J:120007 )
• basal cells exhibit reduced levels of cyclobutane pyrimidine dimers (8.7% compared to 12% in wild-type mice) after a total UV dose of 1.0 kJ/m2
• however, no pyridine pirimidone photoproducts accumulate




Genotype
MGI:2663268
cx2
Allelic
Composition		 Ercc8tm1Jhjh/Ercc8tm1Jhjh
Xpctm1Ecf/Xpc+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc8tm1Jhjh mutation (0 available); any Ercc8 mutation (33 available)
Xpctm1Ecf mutation (1 available); any Xpc mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by UV-induction ( J:74959 )
• mutants develop skin tumors after chronic exposure to UVB radiation at an accelerated rate compared to single Ercc8 homozygotes
• mutants exposed to UVB radiation also develop eye tumors, most being hemangiosarcomas




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory