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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cxcl12+
wild type
MGI:2433150
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Cxcl12tm2Tng/Cxcl12+ B6.Cg-Cxcl12tm2Tng MGI:3716371
ht2
 		Cxcl12tm3.1(HBEGF/EGFP)Tng/Cxcl12+ B6.Cg-Cxcl12tm3.1(HBEGF/EGFP)Tng MGI:4838648
ht3
 		Cxcl12tm1.1(KOMP)Vlcg/Cxcl12+ C57BL/6N-Cxcl12tm1.1(KOMP)Vlcg/Ucd MGI:6262230


Genotype
MGI:3716371
ht1
Allelic
Composition		 Cxcl12tm2Tng/Cxcl12+
Genetic
Background		 B6.Cg-Cxcl12tm2Tng
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm2Tng mutation (1 available); any Cxcl12 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:82996 )
• mice are phenotypically normal




Genotype
MGI:4838648
ht2
Allelic
Composition		 Cxcl12tm3.1(HBEGF/EGFP)Tng/Cxcl12+
Genetic
Background		 B6.Cg-Cxcl12tm3.1(HBEGF/EGFP)Tng
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm3.1(HBEGF/EGFP)Tng mutation (0 available); any Cxcl12 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:164657 )
• mice die 5 days after diphtheria toxin treatment with liver necrosis and hemorrhage

hematopoietic system
abnormal hematopoietic system morphology/development ( J:164657 )
• Diphtheria toxin-treated mice exhibit a reduction in CXCL12-abundant reticular cells compared with untreated mice
decreased common myeloid progenitor cell number ( J:164657 )
• Diphtheria toxin-treated mice exhibit a reduction in megakaryocyte and erythrocyte progenitors (MEP) and granulocyte and macrophage progenitors (GMPs) compared with untreated mice
decreased pro-B cell number ( J:164657 )
• in bone marrow following Diphtheria toxin treatment
decreased bone marrow cell number ( J:164657 )
• after Diphtheria toxin treatment
abnormal common lymphocyte progenitor cell morphology ( J:164657 )
• after Diphtheria toxin treatment, the number of common lymphoid progenitors compared with untreated mice
abnormal proerythroblast morphology ( J:164657 )
• Diphtheria toxin-treated mice lack proerythroblasts compared with untreated mice
abnormal hematopoietic stem cell morphology ( J:164657 )
• hematopoietic stem cells in Diphtheria-treated mice not associated with Cxcl12-abundant reticular cells are smaller than associated cells
decreased hematopoietic stem cell number ( J:164657 )
• Diphtheria toxin-treated mice exhibit decreased long-term repopulating hematopoietic stem cells compared with untreated mice
abnormal hematopoietic system physiology ( J:164657 )
• the repopulating unit in Diphtheria toxin-treated mice is reduced compared to in untreated mice
• Diphtheria toxin-treated mice exhibit more quiescent hematopoietic stem cells than in untreated mice
• Diphtheria toxin-treated mice exhibit early myeloid differentiation of hematopoietic stem cells compared with untreated mice
increased B cell apoptosis ( J:164657 )
• Diphtheria toxin-treated mice exhibit increased pro-B cell apoptosis compared with untreated mice
abnormal bone marrow cell physiology ( J:164657 )
• whole bone marrow cells from Diphtheria-treated mice cultured with piogliazone or BMP2 exhibit reduced differentiation into adipocytes or osteoblasts compared with similarly treated cells from untreated mice

liver/biliary system
liver hemorrhage ( J:164657 )
• after Diphtheria toxin treatment
hepatic necrosis ( J:164657 )
• after Diphtheria toxin treatment

cardiovascular system
liver hemorrhage ( J:164657 )
• after Diphtheria toxin treatment

immune system
increased B cell apoptosis ( J:164657 )
• Diphtheria toxin-treated mice exhibit increased pro-B cell apoptosis compared with untreated mice
decreased pro-B cell number ( J:164657 )
• in bone marrow following Diphtheria toxin treatment

cellular
increased B cell apoptosis ( J:164657 )
• Diphtheria toxin-treated mice exhibit increased pro-B cell apoptosis compared with untreated mice




Genotype
MGI:6262230
ht3
Allelic
Composition		 Cxcl12tm1.1(KOMP)Vlcg/Cxcl12+
Genetic
Background		 C57BL/6N-Cxcl12tm1.1(KOMP)Vlcg/Ucd
Cell Lines 18673A-C4
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1(KOMP)Vlcg mutation (1 available); any Cxcl12 mutation (24 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:211773 )
IMPC - UCD

reproductive system
enlarged uterus ( J:211773 )
IMPC - UCD
hydrometra ( J:211773 )
IMPC - UCD




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory