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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nfib+
wild type
MGI:2433073
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		\Nfibtm1Rmg/\Nfib+ involves: 129P2/OlaHsd * Black Swiss MGI:3530495
ht2
 		\Nfibtm1Rmg/\Nfib+ involves: 129P2/OlaHsd * C57BL/6 MGI:3530500
ht3
 		\Nfibtm1Rmg/\Nfib+ involves: 129P2/OlaHsd * FVB/N MGI:3530503
ht4
 		\Nfibtm1Hsch/\Nfib+ involves: 129S1/Sv * C57BL/6 MGI:3653744


Genotype
MGI:3530495
ht1
Allelic
Composition		 \Nfibtm1Rmg/\Nfib+
Genetic
Background		 involves: 129P2/OlaHsd * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfibtm1Rmg mutation (1 available); any Nfib mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:96006 )
• ~60% survive 24 hours after birth

respiratory system
abnormal lung development ( J:96006 )
• E17.5 lungs had a developmental delay in maturation
small lung saccule ( J:96006 )
• E17.5 lungs had smaller saccules

nervous system
abnormal glial cell morphology ( J:96006 )
• although all three midline glial populations are present, the indusium griseum glia appeared disorganized
abnormal corpus callosum morphology ( J:96006 )
• displayed agenesis of the corpus callosum with the formation of Probst bundles at the midline
• although all three midline glial populations are present, the indusium griseum glia appeared disorganized

cellular
abnormal glial cell morphology ( J:96006 )
• although all three midline glial populations are present, the indusium griseum glia appeared disorganized




Genotype
MGI:3530500
ht2
Allelic
Composition		 \Nfibtm1Rmg/\Nfib+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfibtm1Rmg mutation (1 available); any Nfib mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:96006 )
• only about 55% survive to 14 days after birth

respiratory system
abnormal lung development ( J:96006 )
• E17.5 lungs had a developmental delay in maturation
small lung saccule ( J:96006 )
• E17.5 lungs had smaller saccules

nervous system
abnormal glial cell morphology ( J:96006 )
• reduction in all three midline glial populations of the corpus callosum
abnormal corpus callosum morphology ( J:96006 )
• displayed a less severe callosal phenotype with the formation of Probst bundles at the midline than heterozygotes on the mixed Black Swiss background
• reduction in all three midline glial populations of the corpus callosum

cellular
abnormal glial cell morphology ( J:96006 )
• reduction in all three midline glial populations of the corpus callosum




Genotype
MGI:3530503
ht3
Allelic
Composition		 \Nfibtm1Rmg/\Nfib+
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfibtm1Rmg mutation (1 available); any Nfib mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:96006 )
N
• little or no loss of heterozygotes at 14 days after birth

respiratory system
abnormal lung development ( J:96006 )
• E17.5 lungs had a developmental delay in maturation
small lung saccule ( J:96006 )
• E17.5 lungs had smaller saccules




Genotype
MGI:3653744
ht4
Allelic
Composition		 \Nfibtm1Hsch/\Nfib+
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfibtm1Hsch mutation (0 available); any Nfib mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal lung development ( J:75698 )
• heterozygous mutant lungs are arrested at the late canalicular stage with only focal transition of tissue to the terminal sac stage
• the already developed terminal sacs protect heterozygotes from death due to asphyxia; as a result, all heterozygotes survive and appear overtly normal
• continued postnatal maturation of lungs proceeds and lung histology is indistinguishable from that of wild-type mice at 8 weeks postpartum
abnormal lung saccule morphology ( J:75698 )
• at E18.5, only a few terminal sacs surrounded by thick mesenchyme are observed
thick lung-associated mesenchyme ( J:75698 )
• at E18.6, heterozygous mutant lungs display a larger mesenchymal compartment and thicker interalveolar septae
increased wet-to-dry lung weight ratio ( J:75698 )
• heterozygous mutant lungs have a 16% higher wet weight than wild-type lungs, despite normal size and lobation; however, no difference in lung dry weight is observed
pulmonary hypoplasia ( J:75698 )
• at E18.5 and shortly after birth, heterozygous mutant lungs are slightly hypoplastic and premature relative to wild-type lungs




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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory