Phenotypes associated with this allele

• Allele Symbol: Vdr⁺
• Allele Name: wild type
• Allele ID: MGI:2433036
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Vdr^tm1Mbd/Vdr^+	involves: 129S4/SvJae	MGI:5501523
ht2	Vdr^tm1Mbd/Vdr^+	involves: 129S4/SvJae * C57BL/6	MGI:3798173
ht3	Vdr^tm2.1Ska/Vdr^+	involves: C57BL/6 * CBA/JNCrlj * SJL	MGI:5501522

Genotype
MGI:5501523

ht1

• Allelic Composition: Vdr^tm1Mbd/Vdr⁺
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

increased bone mineral density ( J:196471 )

• at 16 weeks

increased trabecular bone volume ( J:196471 )

increased bone mass ( J:196471 )

• without overt rachitic abnormalities

Genotype
MGI:3798173

ht2

• Allelic Composition: Vdr^tm1Mbd/Vdr⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

cardiovascular system

cardiovascular system phenotype ( J:120353 )

N • plasma levels of angiotensin II or aldosterone are not different from wild-type

N • ECG analysis does not reveal any significant differences from wild-type at 3, 6, or 9 months

increased heart weight ( J:120353 )

• heart weight to body weight ratio is increased 14% relative to wild-type

growth/size/body

increased heart weight ( J:120353 )

• heart weight to body weight ratio is increased 14% relative to wild-type

Genotype
MGI:5501522

ht3

• Allelic Composition: Vdr^tm2.1Ska/Vdr⁺
• Genetic Background: involves: C57BL/6 * CBA/JNCrlj * SJL

skeleton

increased bone mineral density ( J:196471 )

increased trabecular bone volume ( J:196471 )

increased bone mass ( J:196471 )

• at 18 weeks without overt rachitic abnormalities