About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wnt11+
wild type
MGI:2432859
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt11tm1Amc/Wnt11+ 		involves: 129 * C57BL/6 MGI:5444716
cx2
 		Rettm1Cos/Ret+
Wnt11tm1Amc/Wnt11+ 		involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1 MGI:2665016


Genotype
MGI:5444716
cx1
Allelic
Composition		 Fzd2tm1.1Nat/Fzd2+
Fzd7tm1.1Nat/Fzd7tm1.1Nat
Wnt11tm1Amc/Wnt11+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd2tm1.1Nat mutation (1 available); any Fzd2 mutation (32 available)
Fzd7tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)
Wnt11tm1Amc mutation (3 available); any Wnt11 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:189062 )
• 100% of embryos (n=10) display cardiac defects
ventricular septal defect ( J:189062 )
• most defects are VSDs

craniofacial
cleft palate ( J:189062 )
• in 11% of embryos (n=9)

digestive/alimentary system
cleft palate ( J:189062 )
• in 11% of embryos (n=9)

growth/size/body
cleft palate ( J:189062 )
• in 11% of embryos (n=9)




Genotype
MGI:2665016
cx2
Allelic
Composition		 Rettm1Cos/Ret+
Wnt11tm1Amc/Wnt11+
Genetic
Background		 involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm1Cos mutation (2 available); any Ret mutation (52 available)
Wnt11tm1Amc mutation (3 available); any Wnt11 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
small kidney ( J:83430 )
• kidneys are 52% the size of wild-type at E18.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory