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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pou2f1+
wild type
MGI:2432834
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Pou2f1tm1Shrp/Pou2f1+
Pou2f2tm1Bal/Pou2f2+ 		involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 MGI:3028898
cx2
 		Pou2f1tm1Shrp/Pou2f1+
Sox2tm1.1Vep/Sox2+ 		involves: 129S4/SvJae * C3H/HeN * C57BL/6 MGI:6159076


Genotype
MGI:3028898
cx1
Allelic
Composition		 Pou2f1tm1Shrp/Pou2f1+
Pou2f2tm1Bal/Pou2f2+
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou2f1tm1Shrp mutation (1 available); any Pou2f1 mutation (98 available)
Pou2f2tm1Bal mutation (0 available); any Pou2f2 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:87664 )
• many transheterozygous mutants die within 24 hours of birth
postnatal lethality, incomplete penetrance ( J:87664 )
• a subset of mutants surviving birth die prior to weaning

behavior/neurological
lethargy ( J:87664 )
• surviving neonates become increasingly lethargic and runted

growth/size/body
decreased body weight ( J:87664 )
• surviving neonates have lower body weights




Genotype
MGI:6159076
cx2
Allelic
Composition		 Pou2f1tm1Shrp/Pou2f1+
Sox2tm1.1Vep/Sox2+
Genetic
Background		 involves: 129S4/SvJae * C3H/HeN * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou2f1tm1Shrp mutation (1 available); any Pou2f1 mutation (98 available)
Sox2tm1.1Vep mutation (0 available); any Sox2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal lens morphology ( J:119175 )
• lens dysmorphology due to reduced Pax6 dosage; degree of dysmorphology is not exacerbated by reduction of Sox2 dosage
• at E12.5, lenses are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory