All Phenotypes Pou2f2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pou2f2⁺
wild type
MGI:2432833

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pou2f2^tm1Bal/Pou2f2⁺	involves: 129S2/SvPas	MGI:3765427
cx2	Pou2f1^tm1Shrp/Pou2f1⁺ Pou2f2^tm1Bal/Pou2f2⁺	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6	MGI:3028898

Allelic Composition	Pou2f2^tm1Bal/Pou2f2⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou2f2^tm1Bal mutation (0 available); any Pou2f2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:4555 )

• mature B cells in the liver are reduced compared to in wild-type mice but not as severely as in homozygous mice

decreased IgG1 level ( J:4555 )

• cultured liver and spleen cells produce less IgG1 than wild-type cells but more than homozygous cells

decreased IgM level ( J:4555 )

• cultured liver and spleen cells produce less IgM than wild-type cells but more than homozygous cells

hematopoietic system

decreased mature B cell number ( J:4555 )

• mature B cells in the liver are reduced compared to in wild-type mice but not as severely as in homozygous mice

decreased IgG1 level ( J:4555 )

• cultured liver and spleen cells produce less IgG1 than wild-type cells but more than homozygous cells

decreased IgM level ( J:4555 )

• cultured liver and spleen cells produce less IgM than wild-type cells but more than homozygous cells

Allelic Composition	Pou2f1^tm1Shrp/Pou2f1⁺ Pou2f2^tm1Bal/Pou2f2⁺
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou2f1^tm1Shrp mutation (1 available); any Pou2f1 mutation (98 available)
Pou2f2^tm1Bal mutation (0 available); any Pou2f2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:87664 )

• many transheterozygous mutants die within 24 hours of birth

postnatal lethality, incomplete penetrance ( J:87664 )

• a subset of mutants surviving birth die prior to weaning

behavior/neurological

lethargy ( J:87664 )

• surviving neonates become increasingly lethargic and runted

growth/size/body

decreased body weight ( J:87664 )

• surviving neonates have lower body weights

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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