All Phenotypes Pou3f4<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pou3f4^del-J/Pou3f4⁺	C3HeB/FeJ-Pou3f4^del-J/J	MGI:3698745
ht2	Pou3f4^tm1Tno/Pou3f4⁺	involves: 129S4/SvJae * C57BL/6	MGI:3688625

Allelic Composition	Pou3f4^del-J/Pou3f4⁺
Genetic Background	C3HeB/FeJ-Pou3f4^del-J/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou3f4^del-J mutation (1 available); any Pou3f4 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

absent linear vestibular evoked potential ( J:116914 )

• in one of two mice tested, VESPs are absent at the maximum stimulus intensity used

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal cochlea morphology ( J:108889 )

detached Reissner membrane ( J:108889 )

• at >1 year, all female heterozygotes with profound hearing loss show detachment of the Reissner's membrane

abnormal type II spiral ligament fibrocytes ( J:108889 )

• at >1 year, all female heterozygotes with profound hearing loss show ballooning of type II fibrocytes in the suprastrial zone

increased or absent threshold for auditory brainstem response ( J:108889 )

• at 11-15 weeks, young female heterozygotes display a normal range of ABR thresholds of 24.1 +/- 3.5 dB SPL, similar to those of wild-type females

• however, at >1 year, about one-third of female heterozygotes exhibit an average ABR threshold of 96.3 +/- 6.5; the remainder display ABR thresholds within the normal range

deafness ( J:108889 )

• at >1 year, about one-third of aged female heterozygotes exhibit late-onset profound deafness

• the remainder show only a moderate hearing loss falling within the range of hearing loss noted in age-matched wild-type females

skeleton

abnormal type II spiral ligament fibrocytes ( J:108889 )

• at >1 year, all female heterozygotes with profound hearing loss show ballooning of type II fibrocytes in the suprastrial zone

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