All Phenotypes Iglc1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Iglc1⁺
wild type
MGI:2432591

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Iglc1^tm2Ust/Iglc1⁺	involves: 129S7/SvEvBrd * C57BL/6J	MGI:4818912
cx2	Igk^tm1Dhu/Igk^tm1Dhu Iglc1^tm1Ust/Iglc1⁺	involves: 129S7/SvEvBrd * C57BL/6	MGI:3719658
cx3	Igk^tm1Dhu/Igk^tm1Dhu Iglc1^tm1.1Ust/Iglc1⁺	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:3719657

Allelic Composition	Iglc1^tm2Ust/Iglc1⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iglc1^tm2Ust mutation (0 available); any Iglc1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal immunoglobulin light chain V-J recombination ( J:74717 )

• VJ lamda 1 rearrangement is enhanced, however most of the rearrangements are nonproductive

• frequency of productive lamda 1 rearrangements is reduced about 10-fold

immune system

abnormal immunoglobulin light chain V-J recombination ( J:74717 )

• VJ lamda 1 rearrangement is enhanced, however most of the rearrangements are nonproductive

• frequency of productive lamda 1 rearrangements is reduced about 10-fold

Allelic Composition	Igk^tm1Dhu/Igk^tm1Dhu Iglc1^tm1Ust/Iglc1⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igk^tm1Dhu mutation (2 available); any Igk mutation (33 available)
Iglc1^tm1Ust mutation (0 available); any Iglc1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:68144 )

• VJ (variable/joint)recombination is increased 2-fold relative to wild-type levels in the spleen

increased B cell number ( J:68144 )

• the number of lambda1 B cells is increased relative to wild-type mice in the bone marrow and spleen

hematopoietic system

abnormal B cell differentiation ( J:68144 )

• VJ (variable/joint)recombination is increased 2-fold relative to wild-type levels in the spleen

increased B cell number ( J:68144 )

• the number of lambda1 B cells is increased relative to wild-type mice in the bone marrow and spleen

Allelic Composition	Igk^tm1Dhu/Igk^tm1Dhu Iglc1^tm1.1Ust/Iglc1⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igk^tm1Dhu mutation (2 available); any Igk mutation (33 available)
Iglc1^tm1.1Ust mutation (0 available); any Iglc1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell number ( J:68144 )

• lambda1 B cells numbers are reduced to 38.8% from 63.6% in Igl-C1^tm1Ust/ Igl-C1⁺ Igk^tm1Dhu/ Igk^tm1Dhu mice

hematopoietic system

decreased B cell number ( J:68144 )

• lambda1 B cells numbers are reduced to 38.8% from 63.6% in Igl-C1^tm1Ust/ Igl-C1⁺ Igk^tm1Dhu/ Igk^tm1Dhu mice

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