Phenotypes associated with this allele

• Allele Symbol: Mc1r⁺
• Allele Name: wild type
• Allele ID: MGI:2432566
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mc1r^E-So4J/Mc1r^+	B6.Cg-Mc1r^E-So4J/GrsrJ	MGI:5760240
ht2	Mc1r^E-so/Mc1r^+	involves: C3H	MGI:3690946
ht3	Mc1r^E-so3J/Mc1r^+	involves: CBA/J	MGI:5313704
cx4	A/A Mc1r^E-tob/Mc1r^+	M. m. domesticus poschiavinus	MGI:5629972

Genotype
MGI:5760240

ht1

• Allelic Composition: Mc1r^E-So4J/Mc1r⁺
• Genetic Background: B6.Cg-Mc1r^E-So4J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mc1r^E-So4J/Mc1r⁺ on the left showing darkened tail and ears compared to wild-type sibling on the right

integument

darkened coat color ( J:230486 )

abnormal pinna hair pigmentation ( J:230486 )

• heterozygotes have darker ears and tail than wild-type siblings

abnormal tail hair pigmentation ( J:230486 )

• heterozygotes have darker ears and tail than wild-type siblings

pigmentation

darkened coat color ( J:230486 )

abnormal pinna hair pigmentation ( J:230486 )

• heterozygotes have darker ears and tail than wild-type siblings

abnormal tail hair pigmentation ( J:230486 )

• heterozygotes have darker ears and tail than wild-type siblings

Genotype
MGI:3690946

ht2

• Allelic Composition: Mc1r^E-so/Mc1r⁺
• Genetic Background: involves: C3H

pigmentation

darkened coat color ( J:13077 )

• at maturity flanks are flecked with yellow hairs and bellies may appear dark gray

• appearance is similar to homozygous non-agouti mice

• yellow perineal hairs are present in the first coat distinguishing heterozygotes from homozygotes by 12 days of age

• shows epistatic supression of light bellies in mice heterozygous for A^w. white bellied agouti

abnormal skin pigmentation ( J:13077 )

hyperpigmentation ( J:13077 )

• skin is dark, ears and nipples are especially obvious

integument

darkened coat color ( J:13077 )

• at maturity flanks are flecked with yellow hairs and bellies may appear dark gray

• appearance is similar to homozygous non-agouti mice

• yellow perineal hairs are present in the first coat distinguishing heterozygotes from homozygotes by 12 days of age

• shows epistatic supression of light bellies in mice heterozygous for A^w. white bellied agouti

abnormal skin pigmentation ( J:13077 )

Genotype
MGI:5313704

ht3

• Allelic Composition: Mc1r^E-so3J/Mc1r⁺
• Genetic Background: involves: CBA/J

integument

abnormal pinna hair pigmentation ( J:78801 )

• the coat is agouti but the ears are very dark compared with wild-type

pigmentation

abnormal pinna hair pigmentation ( J:78801 )

• the coat is agouti but the ears are very dark compared with wild-type

Genotype
MGI:5629972

cx4

• Allelic Composition: A/A; Mc1r^E-tob/Mc1r⁺
• Genetic Background: M. m. domesticus poschiavinus

integument

abnormal coat/hair pigmentation ( J:22593 )

• Mc1r^E-tob influences the expression of agouti

darkened coat color ( J:22593 )

• the color is difficult to distinguish from non-agouti black before 8 weeks of age when some agouti hairs appear on the flanks; the back remains darkened

• Mc1r^E-tob/Mc1r^e A/a mice have a darkened back

pigmentation

abnormal coat/hair pigmentation ( J:22593 )

• Mc1r^E-tob influences the expression of agouti

darkened coat color ( J:22593 )

• the color is difficult to distinguish from non-agouti black before 8 weeks of age when some agouti hairs appear on the flanks; the back remains darkened

• Mc1r^E-tob/Mc1r^e A/a mice have a darkened back