Phenotypes associated with this allele

• Allele Symbol: Ttr⁺
• Allele Name: wild type
• Allele ID: MGI:2432463
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ttr^tm2(TTR)Kymm/Ttr^+	B6.Cg-Ttr^tm2(TTR)Kymm	MGI:3838187
ht2	Ttr^tm1Wsb/Ttr^+	involves: 129S/SvEv * MF1	MGI:3848329

Genotype
MGI:3838187

ht1

• Allelic Composition: Ttr^tm2(TTR)Kymm/Ttr⁺
• Genetic Background: B6.Cg-Ttr^tm2(TTR)Kymm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating thyroxine level ( J:146510 )

• circulating T4 levels are decreased by around 10% compared to controls

decreased circulating triiodothyronine level ( J:146510 )

• circulating levels of T3 are slightly decreased in the blood similar to levels in null homozygotes

abnormal circulating protein level ( J:146510 )

• circulating retinol binding protein levels are reduced by over 10%

abnormal retinol level ( J:146510 )

• serum retinol levels are reduced by around 40% compared to controls

Genotype
MGI:3848329

ht2

• Allelic Composition: Ttr^tm1Wsb/Ttr⁺
• Genetic Background: involves: 129S/SvEv * MF1

homeostasis/metabolism

decreased circulating thyroxine level ( J:4183 )

• heterozygotes show an intermediate reduction in total circulating T₄ levels relative to homozygous mutant and wild-type control mice

decreased circulating triiodothyronine level ( J:4183 )

• heterozygotes show an intermediate reduction in total circulating T₃ levels relative to homozygous mutant and wild-type control mice