Phenotypes associated with this allele

• Allele Symbol: Sell⁺
• Allele Name: wild type
• Allele ID: MGI:2432082
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Sell^tm1Pest/Sell^+	involves: 129S4/SvJae * C57BL/6	MGI:3664424
ht2	Sell^tm1Flv/Sell^+	involves: C57BL/6 * NOD	MGI:3039434
ht3	Sell^tm1Flv/Sell^+	NOD.Cg-Sell^tm1Flv	MGI:3039437

Genotype
MGI:3664424

ht1

• Allelic Composition: Sell^tm1Pest/Sell⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired leukocyte tethering or rolling ( J:112550 )

• leukocytes from heterozygotes show ~50% of wild-type levels of rolling along high endothelial venules (HEV)

abnormal hypersensitivity reaction ( J:112550 )

• response of sensitized mice to DFNB (contact hypersensitivity) is not significantly different from wild-type mice

cellular

impaired leukocyte tethering or rolling ( J:112550 )

• leukocytes from heterozygotes show ~50% of wild-type levels of rolling along high endothelial venules (HEV)

hematopoietic system

impaired leukocyte tethering or rolling ( J:112550 )

• leukocytes from heterozygotes show ~50% of wild-type levels of rolling along high endothelial venules (HEV)

Genotype
MGI:3039434

ht2

• Allelic Composition: Sell^tm1Flv/Sell⁺
• Genetic Background: involves: C57BL/6 * NOD

endocrine/exocrine glands

pancreas inflammation ( J:88947 )

• inflammation of the islet of Langerhans is seen by 9 weeks in heterozygous and wild-type mice

immune system

pancreas inflammation ( J:88947 )

• inflammation of the islet of Langerhans is seen by 9 weeks in heterozygous and wild-type mice

decreased susceptibility to autoimmune diabetes ( J:88947 )

• the incidence of diabetes (blood glucose >250 mg/dl) in these heterozygotes is decreased as a result of incomplete NOD genetic background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:88974

Genotype
MGI:3039437

ht3

• Allelic Composition: Sell^tm1Flv/Sell⁺
• Genetic Background: NOD.Cg-Sell^tm1Flv

immune system

immune system phenotype ( J:88974 )

N • no difference in the incidence of diabetes (blood glucose >250 mg/dl) is seen between heterozygous and wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:88974