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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sord+
wild type
MGI:2432071
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		SordC57BL/Lia/Sord+
Tg(Cryaa-AKR1B1)648Smch/0 		involves: C57BL * CBA MGI:3783858
cx2
 		SordC57BL/Lia/Sord+
Tg(Cryaa-AKR1B1)222Smch/0 		involves: C57BL * CBA MGI:3783861


Genotype
MGI:3783858
cx1
Allelic
Composition		 SordC57BL/Lia/Sord+
Tg(Cryaa-AKR1B1)648Smch/0
Genetic
Background		 involves: C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SordC57BL/Lia mutation (0 available); any Sord mutation (21 available)
Tg(Cryaa-AKR1B1)648Smch mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal homeostasis ( J:106642 )
• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development

vision/eye
cataract ( J:106642 )
• mice injected with streptozotocin are susceptible to diabetic cataract formation, while non-transgenic SorD-deficient mice do not develop cataracts




Genotype
MGI:3783861
cx2
Allelic
Composition		 SordC57BL/Lia/Sord+
Tg(Cryaa-AKR1B1)222Smch/0
Genetic
Background		 involves: C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SordC57BL/Lia mutation (0 available); any Sord mutation (21 available)
Tg(Cryaa-AKR1B1)222Smch mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal homeostasis ( J:106642 )
• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory