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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccl2+
wild type
MGI:2432066
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ccl2tm1Rol/Ccl2+
Mpztm1Msch/Mpz+ 		involves: 129S4/SvJae * 129S7/SvEvBrd MGI:4418726
cx2
 		Ccl2tm1Rol/Ccl2+
Tg(PMP22)C61Clh/0 		involves: 129S4/SvJae * C57BL/6J * CBA/Ca MGI:4819493


Genotype
MGI:4418726
cx1
Allelic
Composition		 Ccl2tm1Rol/Ccl2+
Mpztm1Msch/Mpz+
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl2tm1Rol mutation (2 available); any Ccl2 mutation (23 available)
Mpztm1Msch mutation (0 available); any Mpz mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
neuron degeneration ( J:133028 )
• at 12 months, mice exhibit demyelinating neuropathy unlike wild-type mice that is not as severe as in Mpztm1Msch heterozygotes or Ccl2tm1Rol/Ccl2+ Mpztm1Msch/Mpz+ mice
demyelination ( J:133028 )
• at 12 months but not as severe as in Mpztm1Msch heterozygotes or Ccl2tm1Rol/Ccl2+ Mpztm1Msch/Mpz+ mice

immune system
abnormal macrophage derived foam cell morphology ( J:133028 )
• at 12 months, the number of foam macrophages in the quadriceps nerve is decreased compared to in Ccl2tm1Rol/Ccl2tm1Rol Mpztm1Msch/Mpz+ mice
decreased macrophage cell number ( J:133028 )
• at 6 months, the number of macrophages in the quadriceps nerves is decreased compared to in Mpztm1Msch heterozygotes
• at 12 months, the number of macrophages in the quadriceps nerve is decreased compared to in Mpztm1Msch heterozygotes and Ccl2tm1Rol/Ccl2tm1Rol Mpztm1Msch/Mpz+ mice

hematopoietic system
abnormal macrophage derived foam cell morphology ( J:133028 )
• at 12 months, the number of foam macrophages in the quadriceps nerve is decreased compared to in Ccl2tm1Rol/Ccl2tm1Rol Mpztm1Msch/Mpz+ mice
decreased macrophage cell number ( J:133028 )
• at 6 months, the number of macrophages in the quadriceps nerves is decreased compared to in Mpztm1Msch heterozygotes
• at 12 months, the number of macrophages in the quadriceps nerve is decreased compared to in Mpztm1Msch heterozygotes and Ccl2tm1Rol/Ccl2tm1Rol Mpztm1Msch/Mpz+ mice

cellular
abnormal macrophage derived foam cell morphology ( J:133028 )
• at 12 months, the number of foam macrophages in the quadriceps nerve is decreased compared to in Ccl2tm1Rol/Ccl2tm1Rol Mpztm1Msch/Mpz+ mice




Genotype
MGI:4819493
cx2
Allelic
Composition		 Ccl2tm1Rol/Ccl2+
Tg(PMP22)C61Clh/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl2tm1Rol mutation (2 available); any Ccl2 mutation (23 available)
Tg(PMP22)C61Clh mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
demyelination ( J:158350 )
• myelin phenotype is improved compared to in Tg(PMP22)C61Clh mice

behavior/neurological

immune system
increased macrophage cell number ( J:158350 )
• in the femoral quadriceps nerves at 2 and 6 months of age that is not as severe Tg(PMP22)C61Clh mice

hematopoietic system
increased macrophage cell number ( J:158350 )
• in the femoral quadriceps nerves at 2 and 6 months of age that is not as severe Tg(PMP22)C61Clh mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory