All Phenotypes Sox8<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sox8⁺
wild type
MGI:2431982

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sox8^tm1Weg/Sox8⁺ Sox9^tm2Crm/Sox9^tm2Crm Tg(Nr5a1-cre)5Asc/?	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA	MGI:3719092

Allelic Composition	Sox8^tm1Weg/Sox8⁺ Sox9^tm2Crm/Sox9^tm2Crm Tg(Nr5a1-cre)5Asc/?
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox8^tm1Weg mutation (0 available); any Sox8 mutation (28 available)
Sox9^tm2Crm mutation (1 available); any Sox9 mutation (33 available)
Tg(Nr5a1-cre)5Asc mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

decreased Sertoli cell number ( J:89368 )

• at E18.5, Sertoli cells are absent

absent Leydig cells ( J:89368 )

• at E18.5, Leydig cells are absent

cryptorchism ( J:89368 )

• by E18.5 testes have not descended caudally

abnormal primary sex determination ( J:89368 )

• gonads develop very few or no sex chords

• XY males exhibit ovarian differentiation

sex reversal ( J:89368 )

• 40% of mice undergo sex reversal

endocrine/exocrine glands