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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prm2+
wild type
MGI:2431871
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Prm2tm1Eddy/Prm2+ either: (chimera involves: 129P2/OlaHsd * C57BL/6N) or (chimera involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) MGI:3039836
ht2
 		Prm2em1Hsc/Prm2+ involves: C57BL/6 * DBA/2 MGI:7258113
ht3
 		Prm2em2Hsc/Prm2+ involves: C57BL/6 * DBA/2 MGI:7258114


Genotype
MGI:3039836
ht1
Allelic
Composition		 Prm2tm1Eddy/Prm2+
Genetic
Background		 either: (chimera involves: 129P2/OlaHsd * C57BL/6N) or (chimera involves: 129S1/Sv * 129X1/SvJ * C57BL/6N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prm2tm1Eddy mutation (0 available); any Prm2 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
teratozoospermia ( J:69127 , J:89324 )
• sperm are found with the flagellum attached to the head and with heads narrowed and reduced in curvature (J:69127)
• chimeras with a greater percentage of 129 sperm also have a greater percentage of deformed sperm (J:69127)
• DNA in 129 sperm is not as compacted and released more readily than in B6 sperm (J:69127)
• sperm are found with the flagellum attached to the head and with heads narrowed and reduced in curvature (J:89324)
• chimeras with a greater percentage of 129 sperm also have a greater percentage of deformed sperm (J:89324)
• DNA in 129 sperm is not as compacted as in B6 sperm (J:89324)
immotile sperm ( J:69127 )
• 129 sperm from chimeras is immotile
infertility ( J:69127 , J:89324 )
• both male and female chimeras produce only non-agouti (B6) offspring (J:69127)
• male chimeras produce only non-agouti (B6) offspring (J:89324)
abnormal fertilization ( J:69127 , J:89324 )
• sperm derived from spermatogenic cells with one copy of the mutated allele are unable to fertilize eggs (J:69127)
• sperm derived from spermatogenic cells with one copy of the mutated allele are unable to fertilize eggs in vivo (J:89324)
• following intracytoplasmic sperm injection the majority (86%) of eggs fertilized with 129 sperm only reached the 2 to 6 cell stage (J:89324)

cellular
teratozoospermia ( J:69127 , J:89324 )
• sperm are found with the flagellum attached to the head and with heads narrowed and reduced in curvature (J:69127)
• chimeras with a greater percentage of 129 sperm also have a greater percentage of deformed sperm (J:69127)
• DNA in 129 sperm is not as compacted and released more readily than in B6 sperm (J:69127)
• sperm are found with the flagellum attached to the head and with heads narrowed and reduced in curvature (J:89324)
• chimeras with a greater percentage of 129 sperm also have a greater percentage of deformed sperm (J:89324)
• DNA in 129 sperm is not as compacted as in B6 sperm (J:89324)
immotile sperm ( J:69127 )
• 129 sperm from chimeras is immotile




Genotype
MGI:7258113
ht2
Allelic
Composition		 Prm2em1Hsc/Prm2+
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prm2em1Hsc mutation (0 available); any Prm2 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:243626 )
N
• heterozygous male mice are fertile and produce a normal litter size with no significant alterations in testis weight and morphology, epididymal sperm count, sperm head morphology or sperm motility relative to wild-type males




Genotype
MGI:7258114
ht3
Allelic
Composition		 Prm2em2Hsc/Prm2+
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prm2em2Hsc mutation (0 available); any Prm2 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:243626 )
N
• heterozygous male mice are fertile and produce a normal litter size with no significant alterations in testis weight and morphology, epididymal sperm count, sperm head morphology or sperm motility relative to wild-type males




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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory