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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prkar2b+
wild type
MGI:2431867
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Prkar2btm2Gsm/Prkar2b+ involves: C57BL/6 MGI:3773451
cx2
 		Ay/A
Prkar2btm2Gsm/Prkar2b+ 		involves: C57BL/6 MGI:3773449


Genotype
MGI:3773451
ht1
Allelic
Composition		 Prkar2btm2Gsm/Prkar2b+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar2btm2Gsm mutation (1 available); any Prkar2b mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
decreased percent body fat/body weight ( J:131039 )
• percentage body fat in females is reduced by about 25%
• percentage body fat in males is reduced by about 14%

behavior/neurological
polyphagia ( J:131039 )
• mice are slightly hyperphagic

homeostasis/metabolism
decreased circulating leptin level ( J:131039 )
• leptin level are reduced by about 60%




Genotype
MGI:3773449
cx2
Allelic
Composition		 Ay/A
Prkar2btm2Gsm/Prkar2b+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (80 available); any a mutation (468 available)
Ay mutation (14 available); any a mutation (468 available)
Prkar2btm2Gsm mutation (1 available); any Prkar2b mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
increased percent body fat/body weight ( J:131039 )
• mice have increased percentage of body fat but is 10% less than what is observed in Ay heterozygotes

behavior/neurological
polyphagia ( J:131039 )
• mice have a higher food consumption but is about 10% less than the amount Ay heterozygotes consume

growth/size/body
increased susceptibility to weight gain ( J:131039 )
• mice have increased rate of weight growth compared to wild-type mice but significantly less than in Ay heterozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory