Phenotypes associated with this allele

• Allele Symbol: Rac2⁺
• Allele Name: wild type
• Allele ID: MGI:2431789
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rac2^m1Btlr/Rac2^+	C57BL/6J-Rac2^m1Btlr	MGI:5641247
ht2	Rac2^M2Btlr/Rac2^+	C57BL/6J-Rac2^M2Btlr	MGI:5775063
ht3	Rac2^m3Btlr/Rac2^+	C57BL/6J-Rac2^m3Btlr	MGI:5807146
ht4	Rac2^M4Btlr/Rac2^+	C57BL/6J-Rac2^M4Btlr	MGI:6114689
ht5	Rac2^M5Btlr/Rac2^+	C57BL/6J-Rac2^M5Btlr	MGI:6114716
ht6	Rac2^em1Shl/Rac2^+	involves: C57BL/6	MGI:6473858

Genotype
MGI:5641247

ht1

• Allelic Composition: Rac2^m1Btlr/Rac2⁺
• Genetic Background: C57BL/6J-Rac2^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased IgM level ( J:221478 )

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) intermediate between the wild-type and homozygotes

impaired humoral immune response ( J:221478 )

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) intermediate between the wild-type and homozygotes

hematopoietic system

decreased IgM level ( J:221478 )

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) intermediate between the wild-type and homozygotes

Genotype
MGI:5775063

ht2

• Allelic Composition: Rac2^M2Btlr/Rac2⁺
• Genetic Background: C57BL/6J-Rac2^M2Btlr

hematopoietic system

decreased B-1 B cell number ( J:231801 )

decreased B-1a cell number ( J:231801 )

increased B-1b cell number ( J:231801 )

immune system

decreased B-1 B cell number ( J:231801 )

decreased B-1a cell number ( J:231801 )

increased B-1b cell number ( J:231801 )

Genotype
MGI:5807146

ht3

• Allelic Composition: Rac2^m3Btlr/Rac2⁺
• Genetic Background: C57BL/6J-Rac2^m3Btlr

hematopoietic system

impaired hematopoiesis ( J:236680 )

• slightly

decreased B-1a cell number ( J:236680 )

increased B-1 B cell number ( J:236680 )

immune system

decreased B-1a cell number ( J:236680 )

increased B-1 B cell number ( J:236680 )

Genotype
MGI:6114689

ht4

• Allelic Composition: Rac2^M4Btlr/Rac2⁺
• Genetic Background: C57BL/6J-Rac2^M4Btlr

immune system

decreased CD8-positive, naive alpha-beta T cell number ( J:255273 )

• in the peripheral blood

decreased alpha-beta T cell number ( J:255273 )

• in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:255273 )

decreased CD8-positive, alpha-beta T cell number ( J:255273 )

• in the peripheral blood

increased alpha-beta T cell number ( J:255273 )

increased effector memory CD4-positive, alpha-beta T cell number ( J:255273 )

• in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:255273 )

increased central memory CD8 positive, alpha-beta T cell number ( J:255273 )

• in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:255273 )

• in the peripheral blood

decreased IgG level ( J:255273 )

• diminished recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

decreased IgM level ( J:255273 )

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

increased IgM level ( J:255273 )

• reduced amount of total IgE in the serum was reduced seven days after OVA/Alum challenge

impaired natural killer cell mediated cytotoxicity ( J:255273 )

abnormal cytotoxic T cell physiology ( J:255273 )

• reduced natural killer cell-mediated target cell killing

impaired humoral immune response ( J:255273 )

• diminished recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

hematopoietic system

decreased CD8-positive, naive alpha-beta T cell number ( J:255273 )

• in the peripheral blood

decreased alpha-beta T cell number ( J:255273 )

• in the peripheral blood

decreased CD4-positive, alpha-beta T cell number ( J:255273 )

decreased CD8-positive, alpha-beta T cell number ( J:255273 )

• in the peripheral blood

increased alpha-beta T cell number ( J:255273 )

increased effector memory CD4-positive, alpha-beta T cell number ( J:255273 )

• in the peripheral blood

increased CD8-positive, alpha-beta T cell number ( J:255273 )

increased central memory CD8 positive, alpha-beta T cell number ( J:255273 )

• in the peripheral blood

increased effector memory CD8-positive, alpha-beta T cell number ( J:255273 )

• in the peripheral blood

decreased IgG level ( J:255273 )

• diminished recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

decreased IgM level ( J:255273 )

• diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll)

increased IgM level ( J:255273 )

• reduced amount of total IgE in the serum was reduced seven days after OVA/Alum challenge

impaired natural killer cell mediated cytotoxicity ( J:255273 )

abnormal cytotoxic T cell physiology ( J:255273 )

• reduced natural killer cell-mediated target cell killing

Genotype
MGI:6114716

ht5

• Allelic Composition: Rac2^M5Btlr/Rac2⁺
• Genetic Background: C57BL/6J-Rac2^M5Btlr

immune system

increased CD8-positive, alpha-beta T cell number ( J:255283 )

• in the peripheral blood

hematopoietic system

increased CD8-positive, alpha-beta T cell number ( J:255283 )

• in the peripheral blood

Genotype
MGI:6473858

ht6

• Allelic Composition: Rac2^em1Shl/Rac2⁺
• Genetic Background: involves: C57BL/6

hematopoietic system

abnormal neutrophil morphology ( J:276213 )

• bone marrow neutrophils exhibit elevated F-actin

increased neutrophil cell number ( J:276213 )

• increase in Mac1+ cells in the spleen, indicative of neutrophilia

decreased leukocyte cell number ( J:276213 )

• mice exhibit peripheral lymphopenia

decreased lymphocyte cell number ( J:276213 )

decreased T cell number ( J:276213 )

• more than 20-fold decrease in CD3+ T cells in the circulation, reflecting decreases of both CD4+ and CD8+ cells

• however, splenic B cells are not decreased

decreased alpha-beta T cell number ( J:276213 )

• T-cell receptor alpha-beta+ cells are lower in the spleen

• however, T-cell receptor gamma-delta+ cell numbers are preserved

• both single positive T-cell subsets ae decreased in the spleen, with CD8+ T cells showing a greater decrease than CD4+ T cells

decreased CD4-positive, alpha-beta T cell number ( J:276213 )

decreased CD8-positive, alpha-beta T cell number ( J:276213 )

immune system

abnormal neutrophil morphology ( J:276213 )

• bone marrow neutrophils exhibit elevated F-actin

increased neutrophil cell number ( J:276213 )

• increase in Mac1+ cells in the spleen, indicative of neutrophilia

decreased leukocyte cell number ( J:276213 )

• mice exhibit peripheral lymphopenia

decreased lymphocyte cell number ( J:276213 )

decreased T cell number ( J:276213 )

• more than 20-fold decrease in CD3+ T cells in the circulation, reflecting decreases of both CD4+ and CD8+ cells

• however, splenic B cells are not decreased

decreased alpha-beta T cell number ( J:276213 )

• T-cell receptor alpha-beta+ cells are lower in the spleen

• however, T-cell receptor gamma-delta+ cell numbers are preserved

• both single positive T-cell subsets ae decreased in the spleen, with CD8+ T cells showing a greater decrease than CD4+ T cells

decreased CD4-positive, alpha-beta T cell number ( J:276213 )

decreased CD8-positive, alpha-beta T cell number ( J:276213 )

cellular

oxidative stress ( J:276213 )

• increase in superoxide production in response to the chemotactic peptide fMLF in marrow cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia		DOID:0112061	OMIM:618986	J:276213