All Phenotypes Rac1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rac1⁺
wild type
MGI:2431788

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rac1^em1(IMPC)Mbp/Rac1⁺	C57BL/6N-Rac1^em1(IMPC)Mbp/MbpMmucd	MGI:6461578
cn2	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Rac1^tm1Djk/Rac1⁺ Tg(Msx2-cre)5Rem/0	involves: 129S4/SvJae	MGI:3834608
cn3	Gt(ROSA)26Sor^{tm1(Dkk1)Flng}/Gt(ROSA)26Sor⁺ Rac1^tm1Djk/Rac1⁺ Tg(Msx2-cre)5Rem/0	involves: 129S4/SvJae * 129X1/SvJ	MGI:3834606

Allelic Composition	Rac1^em1(IMPC)Mbp/Rac1⁺
Genetic Background	C57BL/6N-Rac1^em1(IMPC)Mbp/MbpMmucd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rac1^em1(IMPC)Mbp mutation (1 available); any Rac1 mutation (26 available)

Data Sources

IMPC Data for Rac1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyperactivity ( J:211773 )

IMPC - UCD

endocrine/exocrine glands

abnormal testis morphology ( J:211773 )

IMPC - UCD

small testis ( J:211773 )

IMPC - UCD

growth/size/body

enlarged spleen ( J:211773 )

IMPC - UCD

hematopoietic system

increased erythrocyte cell number ( J:211773 )

IMPC - UCD

decreased mean corpuscular hemoglobin ( J:211773 )

IMPC - UCD

abnormal spleen morphology ( J:211773 )

IMPC - UCD

enlarged spleen ( J:211773 )

IMPC - UCD

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - UCD

immune system

abnormal spleen morphology ( J:211773 )

IMPC - UCD

enlarged spleen ( J:211773 )

IMPC - UCD

abnormal lymph node morphology ( J:211773 )

IMPC - UCD

enlarged lymph nodes ( J:211773 )

IMPC - UCD

renal/urinary system

small kidney ( J:211773 )

IMPC - UCD

reproductive system

abnormal testis morphology ( J:211773 )

IMPC - UCD

small testis ( J:211773 )

IMPC - UCD

vision/eye

abnormal eye morphology ( J:211773 )

IMPC - UCD

microphthalmia ( J:211773 )

IMPC - UCD

anophthalmia ( J:211773 )

IMPC - UCD

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Rac1^tm1Djk/Rac1⁺ Tg(Msx2-cre)5Rem/0
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm2Kem mutation (1 available); any Ctnnb1 mutation (51 available)
Rac1^tm1Djk mutation (1 available); any Rac1 mutation (26 available)
Tg(Msx2-cre)5Rem mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal forelimb morphology ( J:145305 )

• most forelimbs lack structures distal to the scapula

absent hindlimb ( J:145305 )

Allelic Composition	Gt(ROSA)26Sor^{tm1(Dkk1)Flng}/Gt(ROSA)26Sor⁺ Rac1^tm1Djk/Rac1⁺ Tg(Msx2-cre)5Rem/0
Genetic Background	involves: 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Dkk1)Flng} mutation (0 available); any Gt(ROSA)26Sor mutation (1062 available)
Rac1^tm1Djk mutation (1 available); any Rac1 mutation (26 available)
Tg(Msx2-cre)5Rem mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

short forelimb ( J:145305 )

• severe forelimb truncation

absent hindlimb ( J:145305 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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