All Phenotypes Pthlh<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pthlh⁺
wild type
MGI:2431752

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pthlh^{tm1a(KOMP)Wtsi}/Pthlh⁺	C57BL/6N-Pthlh^{tm1a(KOMP)Wtsi}/Wtsi	MGI:5706072
ht2	Pthlh^tm1Hmk/Pthlh⁺	involves: 129S2/SvPas	MGI:3617819
ht3	Pthlh^tm1Hmk/Pthlh⁺	involves: 129S2/SvPas * C57BL/6	MGI:3510232
cn4	Pthlh^tm1Hmk/Pthlh⁺ Pth1r^tm1Hmk/Pth1r^tm2Hmk Tg(Bglap2-cre)1Kry/0	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * FVB/N	MGI:3584345
cx5	Pthlh^tm1Hmk/Pthlh⁺ Tg(Col2a1-GAL4)1Amc/0 Tg(UAS-IHH)1Amc/0	involves: 129S2/SvPas * C57BL/6	MGI:3584341

Allelic Composition	Pthlh^{tm1a(KOMP)Wtsi}/Pthlh⁺
Genetic Background	C57BL/6N-Pthlh^{tm1a(KOMP)Wtsi}/Wtsi
Cell Lines	EPD0798_1_C02

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pthlh^{tm1a(KOMP)Wtsi} mutation (1 available); any Pthlh mutation (19 available)

Data Sources

IMPC Data for Pthlh

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal cranium morphology ( J:211773 )

IMPC - WTSI

growth/size/body

abnormal head morphology ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

increased blood urea nitrogen level ( J:211773 )

IMPC - WTSI

skeleton

abnormal cranium morphology ( J:211773 )

IMPC - WTSI

Allelic Composition	Pthlh^tm1Hmk/Pthlh⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pthlh^tm1Hmk mutation (0 available); any Pthlh mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal osteoblast differentiation ( J:100918 )

• the number of osteoblastic cells formed from cultured bone marrow cells is severely decreased

abnormal osteoclast morphology ( J:100918 )

• osteoclast surface relative to bone surface is reduced

decreased osteoblast cell number ( J:100918 )

• increase in apoptotic osteoblastic cells

abnormal trabecular bone morphology ( J:100918 )

• the 3 dimensional structure of the trabecular bone is altered, trabecular separation is increased, and a 50% is seen in the bone volume/tissue volume ratio

• rather than the normal trabecular plates rodlike structures are present and the degree of anisotropy is decreased

abnormal bone ossification ( J:100918 )

• the mineral apposition rate is decreased in the metaphyseal trabecular bone

• injection of the 1-34 amino acid terminal fragment of human parathyroid hormone increases the mineral apposition rate relative to untreated heterozygotes

hematopoietic system

abnormal osteoclast morphology ( J:100918 )

• osteoclast surface relative to bone surface is reduced

immune system

abnormal osteoclast morphology ( J:100918 )

• osteoclast surface relative to bone surface is reduced

cellular

abnormal osteoblast differentiation ( J:100918 )

• the number of osteoblastic cells formed from cultured bone marrow cells is severely decreased

Allelic Composition	Pthlh^tm1Hmk/Pthlh⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pthlh^tm1Hmk mutation (0 available); any Pthlh mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased long bone epiphyseal plate size ( J:99641 )

• growth plate is shorted by about 8%

Allelic Composition	Pthlh^tm1Hmk/Pthlh⁺ Pth1r^tm1Hmk/Pth1r^tm2Hmk Tg(Bglap2-cre)1Kry/0
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pth1r^tm1Hmk mutation (0 available); any Pth1r mutation (28 available)
Pth1r^tm2Hmk mutation (0 available); any Pth1r mutation (28 available)
Pthlh^tm1Hmk mutation (0 available); any Pthlh mutation (19 available)
Tg(Bglap2-cre)1Kry mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased long bone epiphyseal plate size ( J:99641 )

• growth plate is shorted by about 8%

Allelic Composition	Pthlh^tm1Hmk/Pthlh⁺ Tg(Col2a1-GAL4)1Amc/0 Tg(UAS-IHH)1Amc/0
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pthlh^tm1Hmk mutation (0 available); any Pthlh mutation (19 available)
Tg(Col2a1-GAL4)1Amc mutation (0 available)
Tg(UAS-IHH)1Amc mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased long bone epiphyseal plate size ( J:99641 )

• growth plate is shorted by about 8%

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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