All Phenotypes Pdgfrb<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pdgfrb⁺
wild type
MGI:2431668

Summary

15 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pdgfrb^{tm1b(EUCOMM)Hmgu}/Pdgfrb⁺	C57BL/6N-Pdgfrb^{tm1b(EUCOMM)Hmgu}/H	MGI:5757501
cn2	Pdgfrb^{tm14(Pdgfrb)Sor}/Pdgfrb⁺ Tg(Prm-cre)70Og/0	involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6	MGI:5140928
cn3	Pdgfrb^{tm13(Pdgfrb)Sor}/Pdgfrb⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S4/SvJae * C57BL/6 * CBA	MGI:5140925
cn4	Pdgfrb^{tm12(Pdgfrb)Sor}/Pdgfrb⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S4/SvJae * C57BL/6 * CBA	MGI:5140923
cn5	Pdgfrb^{tm14(Pdgfrb)Sor}/Pdgfrb⁺ Meox2^tm1(cre)Sor/Meox2⁺	involves: 129S4/SvJaeSor * C57BL/6	MGI:5140927
cn6	Pdgfrb^{tm13(Pdgfrb)Sor}/Pdgfrb⁺ Meox2^tm1(cre)Sor/Meox2⁺	involves: 129S4/SvJaeSor * C57BL/6	MGI:5140924
cn7	Pdgfrb^{tm12(Pdgfrb)Sor}/Pdgfrb⁺ Meox2^tm1(cre)Sor/Meox2⁺	involves: 129S4/SvJaeSor * C57BL/6	MGI:5140922
cn8	Pdgfrb^{tm14(Pdgfrb)Sor}/Pdgfrb⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S4/SvJaeSor * C57BL/6 * CBA	MGI:5140926
cn9	Pdgfrb^{tm14(Pdgfrb)Sor}/Pdgfrb⁺ Tg(Tek-cre)1Ywa/0	involves: 129S4/SvJaeSor * C57BL/6 * SJL	MGI:5140931
cn10	Pdgfrb^{tm14(Pdgfrb)Sor}/Pdgfrb⁺ Tg(Tagln-cre)1Her/0	involves: 129S4/SvJaeSor * C57BL/6 * SJL	MGI:5140930
cx11	Pdgfrb^tm1Sor/Pdgfrb⁺ Plekha1^{Gt(ROSA)82Sor}/Plekha1^{Gt(ROSA)82Sor}	either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)	MGI:3822996
cx12	Pdgfrb^tm1Sor/Pdgfrb⁺ Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}	either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)	MGI:3823018
cx13	Pdgfrb^tm1Sor/Pdgfrb⁺ Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor}	either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)	MGI:3823002
cx14	Myo1e^{Gt(ROSA)74Sor}/Myo1e^{Gt(ROSA)74Sor} Pdgfrb^tm1Sor/Pdgfrb⁺	involves: 129S4/SvJaeSor * 129S7/SvEvBrd	MGI:3717126
cx15	Pdgfrb^tm1Sor/Pdgfrb⁺ Schip1^{Gt(ROSA)77Sor}/Schip1^{Gt(ROSA)77Sor}	involves: 129S4/SvJaeSor * 129S7/SvEvBrd	MGI:3717127

Allelic Composition	Pdgfrb^{tm1b(EUCOMM)Hmgu}/Pdgfrb⁺
Genetic Background	C57BL/6N-Pdgfrb^{tm1b(EUCOMM)Hmgu}/H
Cell Lines	HEPD0676_4_F11

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrb^{tm1b(EUCOMM)Hmgu} mutation (0 available); any Pdgfrb mutation (85 available)

Data Sources

IMPC Data for Pdgfrb

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

enlarged heart ( J:211773 )

IMPC - HAR

endocrine/exocrine glands

abnormal seminal vesicle morphology ( J:211773 )

IMPC - HAR

growth/size/body

enlarged heart ( J:211773 )

IMPC - HAR

homeostasis/metabolism

decreased circulating fructosamine level ( J:211773 )

IMPC - HAR

increased circulating triglyceride level ( J:211773 )

IMPC - HAR

reproductive system

abnormal seminal vesicle morphology ( J:211773 )

IMPC - HAR

Allelic Composition	Pdgfrb^{tm14(Pdgfrb)Sor}/Pdgfrb⁺ Tg(Prm-cre)70Og/0
Genetic Background	involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrb^{tm14(Pdgfrb)Sor} mutation (1 available); any Pdgfrb mutation (85 available)
Tg(Prm-cre)70Og mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:173602 )

• authors state that the postnatal phenotype is indistinguishable from epiblast-specific cre activation of the floxed allele

growth/size/body

postnatal growth retardation ( J:173602 )

• authors state that the postnatal phenotype is indistinguishable from epiblast-specific cre activation of the floxed allele

Allelic Composition	Pdgfrb^{tm13(Pdgfrb)Sor}/Pdgfrb⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)
Pdgfrb^{tm13(Pdgfrb)Sor} mutation (1 available); any Pdgfrb mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:173602 )

• usually by P14

growth/size/body

postnatal growth retardation ( J:173602 )

• during the second week

cardiovascular system

increased aorta wall thickness ( J:173602 )

• during the second week, mice exhibit thickening of the ascending aorta media compared with wild-type mice

Allelic Composition	Pdgfrb^{tm12(Pdgfrb)Sor}/Pdgfrb⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)
Pdgfrb^{tm12(Pdgfrb)Sor} mutation (0 available); any Pdgfrb mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:173602 )

• mice are viable and fertile

Allelic Composition	Pdgfrb^{tm14(Pdgfrb)Sor}/Pdgfrb⁺ Meox2^tm1(cre)Sor/Meox2⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Pdgfrb^{tm14(Pdgfrb)Sor} mutation (1 available); any Pdgfrb mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:173602 )

• usually by P14

growth/size/body

postnatal growth retardation ( J:173602 )

• during the second week

Allelic Composition	Pdgfrb^{tm13(Pdgfrb)Sor}/Pdgfrb⁺ Meox2^tm1(cre)Sor/Meox2⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Pdgfrb^{tm13(Pdgfrb)Sor} mutation (1 available); any Pdgfrb mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:173602 )

• usually by P14

growth/size/body

postnatal growth retardation ( J:173602 )

• during the second week

Allelic Composition	Pdgfrb^{tm12(Pdgfrb)Sor}/Pdgfrb⁺ Meox2^tm1(cre)Sor/Meox2⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Pdgfrb^{tm12(Pdgfrb)Sor} mutation (0 available); any Pdgfrb mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:173602 )

• mice are viable and fertile

Allelic Composition	Pdgfrb^{tm14(Pdgfrb)Sor}/Pdgfrb⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)
Pdgfrb^{tm14(Pdgfrb)Sor} mutation (1 available); any Pdgfrb mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:173602 )

• usually by P14

cardiovascular system

abnormal ascending aorta morphology ( J:173602 )

• during the second week, mice exhibit thickening of the ascending aorta compared with wild-type mice

adipose tissue

adipose tissue phenotype ( J:173602 )

N	• at P13, mice exhibit normal interscapular brown adipose tissue

abnormal inguinal fat pad morphology ( J:173602 )

• at P13, inguinal white adipose tissue contains reduced lipids but higher cell density compared to in wild-type mice

abnormal mesenteric fat pad morphology ( J:173602 )

• at P13, only rudimentary mesenteric adipose depots are detected compared to in wild-type mice

abnormal white adipose tissue morphology ( J:173602 )

• at P9, white adipose tissue exhibit a 1.5-fold increase in the stromal vascular fraction compared with wild-type tissue

abnormal white fat cell differentation ( J:173602 )

• subcutaneous mesenchymal cells exhibit reduced white adipocyte differentiation in vitro compared with wild-type cells

increased white fat cell number ( J:173602 )

• at P13, inguinal and subcutaneous white adipose tissues contain reduced lipids but higher cell density compared to in wild-type mice

abnormal hypodermis fat layer morphology ( J:173602 )

• at P13, subcutaneous white adipose tissue contains reduced lipids but higher cell density compared to in wild-type mice

growth/size/body

postnatal growth retardation ( J:173602 )

• during the second week

integument

abnormal hypodermis fat layer morphology ( J:173602 )

• at P13, subcutaneous white adipose tissue contains reduced lipids but higher cell density compared to in wild-type mice

cellular

abnormal white fat cell differentation ( J:173602 )

• subcutaneous mesenchymal cells exhibit reduced white adipocyte differentiation in vitro compared with wild-type cells

Allelic Composition	Pdgfrb^{tm14(Pdgfrb)Sor}/Pdgfrb⁺ Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrb^{tm14(Pdgfrb)Sor} mutation (1 available); any Pdgfrb mutation (85 available)
Tg(Tek-cre)1Ywa mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:173602 )

• mice exhibit no distinguishable phenotype

Allelic Composition	Pdgfrb^{tm14(Pdgfrb)Sor}/Pdgfrb⁺ Tg(Tagln-cre)1Her/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrb^{tm14(Pdgfrb)Sor} mutation (1 available); any Pdgfrb mutation (85 available)
Tg(Tagln-cre)1Her mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:173602 )

N	• mice exhibit normal survival

cardiovascular system

abnormal aorta morphology ( J:173602 )

• mice exhibit alterations in the ascending aorta at 2 weeks that progresses through the arch and descending aorta to affect the entire thoracic and abdominal aorta by 4 weeks unlike in wild-type mice

• mice exhibit reduced periaortic adipose compared to in wild-type mice

abnormal aorta tunica media morphology ( J:173602 )

• thickened

increased aorta wall thickness ( J:173602 )

• authors state that mice exhibit the aorta phenotype observed in mice expressing the floxed allele and Tg(Sox2-cre)1Amc

• however, aorta histology is normal in neonates

abnormal descending aorta morphology ( J:173602 )

• by 4 weeks

abnormal abdominal aorta morphology ( J:173602 )

• by 4 weeks

abnormal thoracic aorta morphology ( J:173602 )

• by 4 weeks

abnormal aortic arch morphology ( J:173602 )

• by 4 weeks

dilated aorta ( J:173602 )

• increased radius

• 2-fold dilation that reaches homeostasis without rupture or apoptosis of vascular smooth muscle cells

abnormal capillary morphology ( J:173602 )

• at P7, retinal capillary size is increased compared to in wild-type mice

• at P12, brain capillary size is increased compared to in wild-type mice

abnormal brain vasculature morphology ( J:173602 )

• reduced vessel density

abnormal retina vasculature morphology ( J:173602 )

• reduced vessel density

abnormal pericyte morphology ( J:173602 )

• pericyte coverage of brain and retinal vasculature is increased compared to in wild-type mice

vascular smooth muscle hyperplasia ( J:173602 )

• mice exhibit increased vascular smooth muscle cell cellularity within the aorta compared with wild-type mice

increased vascular smooth muscle cell proliferation ( J:173602 )

• at E18.5, mice exhibit increased vascular smooth muscle cell (VSMC) proliferation in the aorta compared with wild-type mice

• cultured aorta release >4-fold more VSMCs due to increased proliferation compared with wild-type cultures

adipose tissue

abnormal adipose tissue morphology ( J:173602 )

• mice exhibit reduced periaortic adipose compared to in wild-type mice

growth/size/body

growth/size/body region phenotype ( J:173602 )

N	• mice exhibit normal growth

muscle

vascular smooth muscle hyperplasia ( J:173602 )

• mice exhibit increased vascular smooth muscle cell cellularity within the aorta compared with wild-type mice

increased vascular smooth muscle cell proliferation ( J:173602 )

• at E18.5, mice exhibit increased vascular smooth muscle cell (VSMC) proliferation in the aorta compared with wild-type mice

• cultured aorta release >4-fold more VSMCs due to increased proliferation compared with wild-type cultures

nervous system

abnormal brain vasculature morphology ( J:173602 )

• reduced vessel density

vision/eye

abnormal retina vasculature morphology ( J:173602 )

• reduced vessel density

cellular

increased vascular smooth muscle cell proliferation ( J:173602 )

• at E18.5, mice exhibit increased vascular smooth muscle cell (VSMC) proliferation in the aorta compared with wild-type mice

• cultured aorta release >4-fold more VSMCs due to increased proliferation compared with wild-type cultures

Allelic Composition	Pdgfrb^tm1Sor/Pdgfrb⁺ Plekha1^{Gt(ROSA)82Sor}/Plekha1^{Gt(ROSA)82Sor}
Genetic Background	either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrb^tm1Sor mutation (1 available); any Pdgfrb mutation (85 available)
Plekha1^{Gt(ROSA)82Sor} mutation (1 available); any Plekha1 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

male infertility ( J:142042 )

Allelic Composition	Pdgfrb^tm1Sor/Pdgfrb⁺ Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}
Genetic Background	either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrb^tm1Sor mutation (1 available); any Pdgfrb mutation (85 available)
Sgpl1^{Gt(ROSA)78Sor} mutation (1 available); any Sgpl1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

female infertility ( J:142042 )

male infertility ( J:142042 )

Allelic Composition	Pdgfrb^tm1Sor/Pdgfrb⁺ Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor}
Genetic Background	either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrb^tm1Sor mutation (1 available); any Pdgfrb mutation (85 available)
Tiparp^{Gt(ROSA)79Sor} mutation (1 available); any Tiparp mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

female infertility ( J:142042 )

Allelic Composition	Myo1e^{Gt(ROSA)74Sor}/Myo1e^{Gt(ROSA)74Sor} Pdgfrb^tm1Sor/Pdgfrb⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo1e^{Gt(ROSA)74Sor} mutation (1 available); any Myo1e mutation (91 available)
Pdgfrb^tm1Sor mutation (1 available); any Pdgfrb mutation (85 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:117491 )

N	• anemia seen in Myo1e^{Gt(ROSA)74Sor} is rescued

renal/urinary system

abnormal renal glomerulus morphology ( J:117491 )

• glomeruli are often swollen and degraded

• smooth muscle cell number is reduced in the glomeruli

abnormal kidney physiology ( J:117491 )

• decrease in kidney function

muscle

abnormal smooth muscle morphology ( J:117491 )

• smooth muscle cell number is reduced in the glomeruli

homeostasis/metabolism

increased blood urea nitrogen level ( J:117491 )

Allelic Composition	Pdgfrb^tm1Sor/Pdgfrb⁺ Schip1^{Gt(ROSA)77Sor}/Schip1^{Gt(ROSA)77Sor}
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrb^tm1Sor mutation (1 available); any Pdgfrb mutation (85 available)
Schip1^{Gt(ROSA)77Sor} mutation (1 available); any Schip1 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal skeleton morphology ( J:117491 )

• skeletal defects are more severe than in Schip1^{Gt(ROSA)77Sor} homozygotes

renal/urinary system

abnormal renal glomerulus morphology ( J:117491 )

• glomeruli are often swollen and degraded

• smooth muscle cell number is reduced in the glomeruli

abnormal kidney physiology ( J:117491 )

• decrease in kidney function

homeostasis/metabolism

increased blood urea nitrogen level ( J:117491 )

muscle

abnormal smooth muscle morphology ( J:117491 )

• smooth muscle cell number is reduced in the glomeruli

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