Phenotypes associated with this allele

• Allele Symbol: Pcsk1⁺
• Allele Name: wild type
• Allele ID: MGI:2431657
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pcsk1^tm1b(EUCOMM)Wtsi/Pcsk1^+	C57BL/6N-Pcsk1^tm1b(EUCOMM)Wtsi/Ics	MGI:5757488
ht2	Pcsk1^tm1Dfs/Pcsk1^+	involves: 129 * C57BL/6J	MGI:3054394
ht3	Pcsk1^tm1Mbi/Pcsk1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	MGI:3715033

Genotype
MGI:5757488

ht1

• Allelic Composition: Pcsk1^{tm1b(EUCOMM)Wtsi}/Pcsk1⁺
• Genetic Background: C57BL/6N-Pcsk1^{tm1b(EUCOMM)Wtsi}/Ics
• Cell Lines: EPD0508_1_C08

Data Sources

IMPC Data for Pcsk1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal freezing behavior ( J:211773 )

♀

IMPC - ICS

decreased locomotor activity ( J:211773 )

♀

IMPC - ICS

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

♂

IMPC - ICS

abnormal retina blood vessel morphology ( J:211773 )

♂

IMPC - ICS

vision/eye

abnormal retina vasculature morphology ( J:211773 )

♂

IMPC - ICS

abnormal retina blood vessel morphology ( J:211773 )

♂

IMPC - ICS

abnormal vitreous body morphology ( J:211773 )

♂

IMPC - ICS

persistence of hyaloid vascular system ( J:211773 )

♂

IMPC - ICS

Genotype
MGI:3054394

ht2

• Allelic Composition: Pcsk1^tm1Dfs/Pcsk1⁺
• Genetic Background: involves: 129 * C57BL/6J

growth/size/body

obese ( J:78369 )

• mild obesity

homeostasis/metabolism

decreased circulating insulin level ( J:78369 )

• reduced levels of mature insulin

abnormal glucose tolerance ( J:78369 )

• prolonged glycemic response in response to glucose tolerance test

Genotype
MGI:3715033

ht3

• Allelic Composition: Pcsk1^tm1Mbi/Pcsk1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

growth/size/body

slow postnatal weight gain ( J:122555 )

• after 13 weeks on a low fat diet, females show less weight gain (9%) than wild-type females (26%); male heterozygotes gain a comparable amount of weight as wild-type mice

increased susceptibility to diet-induced obesity ( J:122555 )

• on a high fat diet, female heterozygotes gain 43% more weight on a high fat diet compared to a 9% weight gain on a low fat diet; both heterozygous and wild-type males show more weight gain (40%) than shown when on low fat diet (~23%)

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:122555 )

N • no significant differences are seen between heterozygous and wild-type mice in fasting glycemia after 13 weeks of low fat or high fat diet, or in glycemic response to intraperitoneal glucose injection

increased susceptibility to diet-induced obesity ( J:122555 )

• on a high fat diet, female heterozygotes gain 43% more weight on a high fat diet compared to a 9% weight gain on a low fat diet; both heterozygous and wild-type males show more weight gain (40%) than shown when on low fat diet (~23%)

reproductive system

transmission ratio distortion ( J:122555 )

• frequency of mutant allele among surviving embryos (after implantation to weaning age) is consistently >80%, instead of the expected 66.7%