Analysis Tools|
Allele Symbol Allele Name Allele ID |
Npr3+ wild type MGI:2431639 |
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| Summary |
2 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• heterozygotes display progressively increased red blood cell counts relative to wild-type mice (10.1 0.3 106/mm3 vs 9.7 0.1 106/mm3, respectively)
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• heterozygotes display progressively increased hematocrits relative to wild-type mice (51.8 0.9 vs 49.9 1.0, respectively)
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• heterozygotes display progressively increased hemoglobin levels relative to wild-type mice (16.2 0.2 g/dl vs 15.6 0.2 g/dl, respectively)
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• homozygotes exhibit a >200% increase in total daily excretion of cGMP in the urine relative to wild-type mice
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• heterozygotes can excrete dilute urine after water loading but become progressively and significantly less able to concentrate urine relative to wild-type mice
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• heterozygotes exhibit reduced intravascular blood volume; however, no reduction in blood pressure is observed relative to wild-type mice
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• homozygotes exhibit a >200% increase in total daily excretion of cGMP in the urine relative to wild-type mice
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• heterozygotes can excrete dilute urine after water loading but become progressively and significantly less able to concentrate urine relative to wild-type mice
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• similar to homozygotes, heterozygotes show a mild progressive increase in total daily urine output relative to wild-type littermates
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/18/2025 MGI 6.24 |
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