All Phenotypes Ndn<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ndn⁺
wild type
MGI:2431588

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ndn^tm1.1Mus/Ndn⁺	B6.129S2-Ndn^tm1.1Mus	MGI:3773672
ht2	Ndn^tm1Stw/Ndn⁺	involves: 129S1/Sv * C3H/He * C57BL/6	MGI:2653054
ht3	Ndn^tm2Stw/Ndn⁺	involves: 129S1/Sv * C57BL/6	MGI:2654656
ht4	Ndn^tm1Stw/Ndn⁺	involves: 129S1/Sv * C57BL/6	MGI:2653050
ht5	Ndn^tm1Stw/Ndn⁺	involves: 129S1/Sv * C57BL/6 * CBA	MGI:4365458
ht6	Ndn^tm2Stw/Ndn⁺	involves: 129S1/Sv * C57BL/6J	MGI:2653055
ht7	Ndn^tm1Stw/Ndn⁺	involves: 129S1/Sv * FVB	MGI:2653051
ht8	Ndn^tm1.1Mus/Ndn⁺	involves: 129S2/SvPas * C57BL/6J	MGI:3723649
ht9	Ndn^tm1Alb/Ndn⁺	involves: 129S7/SvEvBrd	MGI:2653070
ht10	Ndn^tm1Ky/Ndn⁺	involves: C57BL/6 * CBA * ICR/Slc	MGI:3607781

Allelic Composition	Ndn^tm1.1Mus/Ndn⁺
Genetic Background	B6.129S2-Ndn^tm1.1Mus

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndn^tm1.1Mus mutation (0 available); any Ndn mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

In vivo analysis of axonal growth in Ndn^tm1.1Mus/Ndn⁺ embryos

behavior/neurological

impaired coordination ( J:119656 )

• time spent in an accelerated rotarod is reduced and the latency to reach the goal platform in the beam walking test is increased in mice with a paternally inherited allele

decreased thermal nociceptive threshold ( J:119656 )

• mice with a paternally inherited allele show reduced withdrawal latency on a hot plate test compared to wild-type, indicating reduced pain threshold

nervous system

abnormal sensory neuron innervation pattern ( J:119656 )

• cutaneous innervation in the hindpad is reduced in mice with a paternally inherited allele, as indicated by reduced number of CGRP-immunoreactive fibers

abnormal dorsal root ganglion morphology ( J:119656 )

• neurite outgrowth from DRG explants isolated from E13.5 mutants with a paternally inherited allele and grown in culture is reduced by 18.3%

abnormal proprioceptive neuron morphology ( J:119656 )

• partial loss of proproceptive (TrkC expressing) sensory neurons in mice with a paternally inherited allele

• afferent projections from the proprioceptive neurons are reduced in the intermediate spinal cord of E17.5 mice with a paternally inherited allele

abnormal lumbar dorsal root ganglion morphology ( J:119656 )

• mice with a paternally inherited allele, show a 37% reduction in the L1 dorsal root ganglia (DRG) volume at P0

• lumbar DRGs of mice with a paternally inherited allele show a reduction of 26.2% in the density of TrkA-expressing cells and a reduction of 37.8% in TrkC-positive neurons

• mutants with a paternally inherited allele exhibit an increase of apoptosis in lumbar DRG at E12.5, restricted to neurons and does not affect progenitors

abnormal nervous system electrophysiology ( J:119656 )

• when this allele is paternally inherited, the monosynaptic reflex response on the plantar muscle shows a higher H-wave amplitude and H/M amplitude ratio

cellular

maternal imprinting ( J:119656 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Prader-Willi syndrome		DOID:11983	OMIM:176270	J:119656

Allelic Composition	Ndn^tm1Stw/Ndn⁺
Genetic Background	involves: 129S1/Sv * C3H/He * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndn^tm1Stw mutation (0 available); any Ndn mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:57890 )

• Background Sensitivity: when chimeric males are bred with (C57BL/6 x C3H)F1 hybrid females, lethality is reduced to wild-type levels

• Background Sensitivity: when homozygous males on the [(C57BL/6 x C3H)F1 x 129S1/Sv] background are mated with C57BL/6 wild-type females, offspring again show high incidence (65%) of mortality

Allelic Composition	Ndn^tm2Stw/Ndn⁺
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndn^tm2Stw mutation (1 available); any Ndn mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:57890 )

• mice inheriting the paternal allele exhibit 98% lethality within 30 hours of birth

respiratory system

respiratory distress ( J:57890 )

• mutants inheriting the mutant allele paternally exhibit respiratory distress shortly after birth; dsypneic with contraction of accessory respiratory muscles and often die at the end of this phase

• a few minutes before death, the respiratory contraction frequency dropped from one gasp every 2 seconds to one every 10-15 seconds and hypotonia is observed

cellular

maternal imprinting ( J:57890 )

• mice inheriting the maternal allele are indistinguishable from wild-type, whereas those inheriting the paternal allele show 98% lethality within 30 hours of birth

homeostasis/metabolism

cyanosis ( J:57890 )

• observed in mice inheriting the mutant allele from the father

muscle

hypotonia ( J:57890 )

• hypotonia is observed a few minutes before death when the mutant allele is paternally inherited

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Prader-Willi syndrome		DOID:11983	OMIM:176270	J:57890

Allelic Composition	Ndn^tm1Stw/Ndn⁺
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndn^tm1Stw mutation (0 available); any Ndn mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:57890 )

• when the mutant allele is paternally inherited, many mutants die within 30 hours of birth, however those surviving the first 30 hours are indistinguishable from wild-type

postnatal lethality ( J:57890 )

• Background Sensitivity: high level of postnatal lethality, especially on a C57BL/6 background, within 30 hours following birth, when the mutant allele is paternally inherited

• Background Sensitivity: male offspring derived from mating of chimeric males with wild-type C57BL/6 females have a higher level of lethality than females, with 95% of males and 40% of females dying

• Background Sensitivity: when the single surviving mutant male is bred with wild-type C57BL/6 females, male and female offspring are equally affected by lethality (80%)

respiratory system

respiratory distress ( J:57890 )

• mutants inheriting the mutant allele paternally exhibit respiratory distress shortly after birth; dsypneic with contraction of accessory respiratory muscles and often die at the end of this phase

• a few minutes before death, the respiratory contraction frequency drops from one gasp every 2 seconds to one every 10-15 seconds and hypotonia is observed

cellular

maternal imprinting ( J:57890 )

• mice inheriting the maternal allele are indistinguishable from wild-type, whereas those inheriting the paternal allele show postnatal lethality due to respiratory distress within 30 hours of birth

homeostasis/metabolism

cyanosis ( J:57890 )

• observe in mice inheriting the mutant allele from the father

muscle

hypotonia ( J:57890 )

• hypotonia is observed a few minutes before death when the mutant allele is paternally inherited

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Prader-Willi syndrome		DOID:11983	OMIM:176270	J:57890

Allelic Composition	Ndn^tm1Stw/Ndn⁺
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndn^tm1Stw mutation (0 available); any Ndn mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:57890 )

N	• Background Sensitivity: when chimeric males are bred with (C57BL/6 x CBA)F1 hybrid females, lethality is reduced to wild-type levels

Allelic Composition	Ndn^tm2Stw/Ndn⁺
Genetic Background	involves: 129S1/Sv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndn^tm2Stw mutation (1 available); any Ndn mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:82266 )

• mice inheriting the mutant allele paternally die a few hours after birth

respiratory system

abnormal respiration ( J:82266 )

• the respiratory motor discharge pattern produced by cervical ventral roots, hypoglossal roots, cranial motoneuron pools and within neurons located in the putative respiratory rhythm-generating center, the pre-Botzinger complex, is very irregular in mice inheriting the mutant allele from the father, with prominent bouts of depression of respiratory rhythmogenesis

respiratory distress ( J:82266 )

• mice inheriting the mutant allele paternally gasp for air when born and turn cyanotic

hypoventilation ( J:82266 )

• mice inheriting the mutant allele paternally exhibit hypoventilation resulting from a defective central respiratory drive

cellular

maternal imprinting ( J:82266 )

homeostasis/metabolism

cyanosis ( J:82266 )

• in mutants with the paternally inherited allele

hypoxia ( J:82266 )

• in mutants with the paternally inherited allele

nervous system

abnormal central pattern generator function ( J:82266 )

• pups with abnormal breathing fail to generate rhythmic motor bursts from cervical or hypoglossal nerve roots in vitro or generate a severely irregular rhythmic motor output

abnormal pre-Botzinger complex physiology ( J:82266 )

• he respiratory motor discharge pattern produced by cervical ventral roots, hypoglossal roots, cranial motoneuron pools and within neurons located in the putative respiratory rhythm-generating center, the pre-Botzinger complex, is very irregular in mice inheriting the mutant allele from the father, with prominent bouts of depression of respiratory rhythmogenesis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Prader-Willi syndrome		DOID:11983	OMIM:176270	J:82266

Allelic Composition	Ndn^tm1Stw/Ndn⁺
Genetic Background	involves: 129S1/Sv * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndn^tm1Stw mutation (0 available); any Ndn mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:57890 )

• Background Sensitivity: when chimeric males are bred with wild-type FVB females, lethality declines from 80% (on a C57BL/6 background) to 25% of mutant offspring, and males are more affected than females

respiratory system

respiratory distress ( J:57890 )

cellular

maternal imprinting ( J:57890 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Prader-Willi syndrome		DOID:11983	OMIM:176270	J:57890

Allelic Composition	Ndn^tm1.1Mus/Ndn⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndn^tm1.1Mus mutation (0 available); any Ndn mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hypothalamus morphology ( J:66557 )

• the number of hypothalamic oxytocin- and luteinizing hormone-releasing hormone-producing neurons is decreased in paternal-deficient heterozygous mice

• paternal-deficient mice showed no gross morphological abnormalities

• general histological makers revealed no obvious differences in brain structure in paternal-deficient heterozygous mice

behavior/neurological

abnormal spatial learning ( J:66557 )

• spatial learning assessed in the Morris water maze test show improved ability of the mutant to remember accurately the location of the platform in paternal-deficient heterozygous mice

excessive scratching ( J:66557 )

• skin scraping was significantly increased in paternal-deficient mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Prader-Willi syndrome		DOID:11983	OMIM:176270	J:66557

Allelic Composition	Ndn^tm1Alb/Ndn⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndn^tm1Alb mutation (0 available); any Ndn mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:55267 )

• heterozygotes carrying a paternally inherited allele are viable, fertile, and do not develop obesity up to 10 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Prader-Willi syndrome	DOID:11983	OMIM:176270	J:55267

Allelic Composition	Ndn^tm1Ky/Ndn⁺
Genetic Background	involves: C57BL/6 * CBA * ICR/Slc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndn^tm1Ky mutation (3 available); any Ndn mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased thermal nociceptive threshold ( J:100024 )

• at P14 and P29 in mice with a paternally inherited allele, latencies in the hotplate and tail-flick test are about 2-fold greater than those of wild-type mice; however, no postnatal lethality is seen when this allele is paternally inherited on an ICR background

nervous system

abnormal dorsal root ganglion morphology ( J:100024 )

• when this allele is paternally inherited a 1.6- to 1.8-fold increase in apoptosis is seen in the cervical dorsal root ganglia at E12.5

• the density of nociceptive neurons (substance P-containing) is reduced to 59% that in wild-type mice at P0

• at P0 the total neuron number is reduced to 88% that in wild-type mice

cellular

maternal imprinting ( J:100024 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Prader-Willi syndrome		DOID:11983	OMIM:176270	J:100024

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