Phenotypes associated with this allele

• Allele Symbol: Pbx1⁺
• Allele Name: wild type
• Allele ID: MGI:2431556
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pbx1^tm1Mlc/Pbx1^+	involves: 129S6/SvEvTac * C57BL/6	MGI:3052679
ht2	Pbx1^tm1.1Febe/Pbx1^+	involves: C57BL/6	MGI:3770153
cn3	Pbx1^tm1Mlc/Pbx1^+ Wnt9b^tm1Amc/Wnt9b^tm1Amc Foxg1^tm1(cre)Skm/Foxg1^+	involves: 129P2/OlaHsd * 129S6/SvEvTac * 129X1/SvJ	MGI:5305933
cx4	Pbx1^tm1Mlc/Pbx1^+ Pbx2^tm1Mlc/Pbx2^+ Pbx3^tm1Mlc/Pbx3^+	involves: 129S6/SvEvTac	MGI:5305931
cx5	Pdx1^tm1Cvw/Pdx1^+ Pbx1^tm1Mlc/Pbx1^+	involves: 129S6/SvEvTac * C57BL/6	MGI:3052685

Genotype
MGI:3052679

ht1

• Allelic Composition: Pbx1^tm1Mlc/Pbx1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:75811 )

• abnormal clustering of islets

decreased insulin secretion ( J:75811 )

• inappropriate decrease in insulin secretion following glucose challenge

growth/size/body

decreased body size ( J:70684 )

homeostasis/metabolism

decreased insulin secretion ( J:75811 )

• inappropriate decrease in insulin secretion following glucose challenge

impaired glucose tolerance ( J:75811 )

increased insulin sensitivity ( J:75811 )

Genotype
MGI:3770153

ht2

• Allelic Composition: Pbx1^tm1.1Febe/Pbx1⁺
• Genetic Background: involves: C57BL/6

endocrine/exocrine glands

decreased adrenal gland zona fasciculata size ( J:129552 )

• mice exhibit a reduction in the number of cells in the zona fasciculate (63.3+/-3.3% compared to 89.3+/-8.3% in wild-type mice)

small adrenal glands ( J:129552 )

• 4.4+/-0.4 mg compared to 7.5+/-0.3 mg in wild-type mice

• adrenal glands are smaller due to decreased proliferation

• adrenal glands exhibit decreased compensatory adrenal growth compared to in wild-type mice when one adrenal is removed

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:129552 )

• mice exhibit a blunted steroid response after stimulation with ACTH

• however, corticosterone response following restrained stress experiments is normal

Genotype
MGI:5305933

cn3

• Allelic Composition: Pbx1^tm1Mlc/Pbx1⁺; Wnt9b^tm1Amc/Wnt9b^tm1Amc; Foxg1^tm1(cre)Skm/Foxg1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * 129X1/SvJ

craniofacial

bilateral cleft upper lip ( J:178316 )

• bilateral cleft lip in all mice

cleft palate ( J:178316 )

digestive/alimentary system

cleft palate ( J:178316 )

growth/size/body

bilateral cleft upper lip ( J:178316 )

• bilateral cleft lip in all mice

cleft palate ( J:178316 )

Genotype
MGI:5305931

cx4

• Allelic Composition: Pbx1^tm1Mlc/Pbx1⁺; Pbx2^tm1Mlc/Pbx2⁺; Pbx3^tm1Mlc/Pbx3⁺
• Genetic Background: involves: 129S6/SvEvTac

craniofacial

cleft palate ( J:178316 )

digestive/alimentary system

cleft palate ( J:178316 )

mortality/aging

neonatal lethality, complete penetrance ( J:178316 )

growth/size/body

cleft palate ( J:178316 )

Genotype
MGI:3052685

cx5

• Allelic Composition: Pdx1^tm1Cvw/Pdx1⁺; Pbx1^tm1Mlc/Pbx1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

endocrine/exocrine glands

disorganized pancreatic islets ( J:75811 )

• disrupted architecture, inappropriate cell types interspersed with beta cells

decreased insulin secretion ( J:75811 )

growth/size/body

weight loss ( J:75811 )

• 9-10 weeks

homeostasis/metabolism

decreased insulin secretion ( J:75811 )

hyperglycemia ( J:75811 )

• onset between 9-10 weeks, progresses to overt diabetes

impaired glucose tolerance ( J:75811 )

increased urine glucose level ( J:75811 )

increased insulin sensitivity ( J:75811 )

renal/urinary system

increased urine glucose level ( J:75811 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:75811