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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mpl+
wild type
MGI:2431516
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Mplhlb219/Mpl+ C57BL/6J-Mplhlb219/J MGI:3841388
ht2
 		Mplem1(IMPC)Ccpcz/Mpl+ C57BL/6NCrl-Mplem1(IMPC)Ccpcz/Ccpcz MGI:7768379


Genotype
MGI:3841388
ht1
Allelic
Composition		 Mplhlb219/Mpl+
Genetic
Background		 C57BL/6J-Mplhlb219/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mplhlb219 mutation (2 available); any Mpl mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal definitive hematopoiesis ( J:146577 )
• mutant mice exhibit a significant increase in the progenitor CFU-GM, CFU-M, and CFU-Mk populations compared to controls
decreased erythrocyte cell number ( J:146577 )
• significantly fewer red blood cells compared to controls




Genotype
MGI:7768379
ht2
Allelic
Composition		 Mplem1(IMPC)Ccpcz/Mpl+
Genetic
Background		 C57BL/6NCrl-Mplem1(IMPC)Ccpcz/Ccpcz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mplem1(IMPC)Ccpcz mutation (1 available); any Mpl mutation (48 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal vocalization ( J:211773 )
IMPC - CCP-IMG

cardiovascular system

growth/size/body
enlarged spleen ( J:211773 )
IMPC - CCP-IMG

hematopoietic system
enlarged spleen ( J:211773 )
IMPC - CCP-IMG

immune system
enlarged spleen ( J:211773 )
IMPC - CCP-IMG




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory