All Phenotypes Msx2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Msx2⁺
wild type
MGI:2431474

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Msx2^tm1Rilm/Msx2⁺	involves: 129S4/SvJae * BALB/c * C57BL/6	MGI:3050889
cx2	Msx2^tm1Rilm/Msx2⁺ Twist1^tm1Bhr/Twist1⁺	involves: 129S4/SvJae * 129S7/SvEvBrd * BALB/c * C57BL/6	MGI:3050895
cx3	Msx1^tm1Rilm/Msx1^tm1Rilm Msx2^tm1Rilm/Msx2⁺	involves: 129S4/SvJae * CD-1	MGI:3050865

Allelic Composition	Msx2^tm1Rilm/Msx2⁺
Genetic Background	involves: 129S4/SvJae * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx2^tm1Rilm mutation (1 available); any Msx2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

frontal bone foramen ( J:87044 )

• heterozygotes exhibit a frontal foramen phenotype that is intermediate in severity relative to wild-type and homozygous mutant mice

skeleton

frontal bone foramen ( J:87044 )

• heterozygotes exhibit a frontal foramen phenotype that is intermediate in severity relative to wild-type and homozygous mutant mice

growth/size/body

frontal bone foramen ( J:87044 )

• heterozygotes exhibit a frontal foramen phenotype that is intermediate in severity relative to wild-type and homozygous mutant mice

Allelic Composition	Msx2^tm1Rilm/Msx2⁺ Twist1^tm1Bhr/Twist1⁺
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx2^tm1Rilm mutation (1 available); any Msx2 mutation (26 available)
Twist1^tm1Bhr mutation (4 available); any Twist1 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

frontal bone foramen ( J:87044 )

• in double heterozygotes, the frontal foramen phenotype is 3x more severe than in either single heterozygote

limbs/digits/tail

polydactyly ( J:87044 )

• in double heterozygotes, the incidence of digit duplication is identical to that observed in Twist1^tm1Bhr heterozygotes (34%)

skeleton

frontal bone foramen ( J:87044 )

• in double heterozygotes, the frontal foramen phenotype is 3x more severe than in either single heterozygote

growth/size/body

frontal bone foramen ( J:87044 )

• in double heterozygotes, the frontal foramen phenotype is 3x more severe than in either single heterozygote

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Saethre-Chotzen syndrome		DOID:14768	OMIM:101400 OMIM:180750	J:87044

Allelic Composition	Msx1^tm1Rilm/Msx1^tm1Rilm Msx2^tm1Rilm/Msx2⁺
Genetic Background	involves: 129S4/SvJae * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1^tm1Rilm mutation (1 available); any Msx1 mutation (19 available)
Msx2^tm1Rilm mutation (1 available); any Msx2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:83306 )

N	• compound mutants display formation of the malleal manubrium

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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