All Phenotypes Ascl2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ascl2⁺
wild type
MGI:2431340

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ascl2^tm1Alj/Ascl2⁺	involves: 129 * CD-1	MGI:3773268
ht2	Ascl2^tm1.1Nagy/Ascl2⁺	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3847333
cx3	Ascl2^tm1Alj/Ascl2⁺ Kcnq1ot1^tm1.1Mjh/Kcnq1ot1⁺	involves: 129 * C57BL/6 * ICR	MGI:3772941

Allelic Composition	Ascl2^tm1Alj/Ascl2⁺
Genetic Background	involves: 129 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ascl2^tm1Alj mutation (0 available); any Ascl2 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:23260 )

• maternal inheritance of the mutant allele leads to embryonic death due to placental failure

• mice whom paternally inherit the mutant allele are viable

embryo

abnormal chorion morphology ( J:23260 )

• chorion membrane is underdeveloped in embryos whom maternally inherit the mutant allele

abnormal spongiotrophoblast layer morphology ( J:23260 )

• spongiotrophoblast fails to develop in embryos whom maternally inherit the mutant allele

cellular

paternal imprinting ( J:23260 )

• the paternal allele is functionally inactivated

• mice whom maternally inherit the mutant allele are functionally null homozygotes and die during embryogenesis

• mice whom paternally inherit the mutant allele are viable

Allelic Composition	Ascl2^tm1.1Nagy/Ascl2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ascl2^tm1.1Nagy mutation (0 available); any Ascl2 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased spongiotrophoblast cell number ( J:57828 )

• when this allele is inherited maternally, mice show reduced spongiotrophoblast cells compared with wild-type mice

• however, mice inheriting this allele paternally exhibit no defects

Allelic Composition	Ascl2^tm1Alj/Ascl2⁺ Kcnq1ot1^tm1.1Mjh/Kcnq1ot1⁺
Genetic Background	involves: 129 * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ascl2^tm1Alj mutation (0 available); any Ascl2 mutation (13 available)
Kcnq1ot1^tm1.1Mjh mutation (0 available); any Kcnq1ot1 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:130399 )

N	• no embryonic lethality is observed in mice maternally inheriting the Ascl2^tm1Alj allele

cellular

abnormal imprinting ( J:130399 )

• embryonic lethality associated with maternal transmission of Ascl2^tm1Alj allele is prevented by the addition of the Kcnq1^tm1.1Mjh allele due to a lack of paternal imprinting of genes in the distal portion of chromosome 7

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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