All Phenotypes Itpr1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Itpr1⁺
wild type
MGI:2431271

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Itpr1^opt/Itpr1⁺	B6C3Fe-a/a-Itpr1^opt/J	MGI:5646183
ht2	Itpr1^{tm1.1(NCOM)Mfgc}/Itpr1⁺	C57BL/6N-Itpr1^{tm1.1(NCOM)Mfgc}/Tcp	MGI:5797609
ht3	Itpr1^em1Drf/Itpr1⁺	Not Specified	MGI:5823157

Allelic Composition	Itpr1^opt/Itpr1⁺
Genetic Background	B6C3Fe-a/a-Itpr1^opt/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itpr1^opt mutation (2 available); any Itpr1 mutation (185 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased insulin secretion ( J:222913 )

• at 3 months following glucose ingestion

homeostasis/metabolism

decreased insulin secretion ( J:222913 )

• at 3 months following glucose ingestion

impaired glucose tolerance ( J:222913 )

• at 3 months following glucose ingestion

Allelic Composition	Itpr1^{tm1.1(NCOM)Mfgc}/Itpr1⁺
Genetic Background	C57BL/6N-Itpr1^{tm1.1(NCOM)Mfgc}/Tcp
Cell Lines	N01968P1_C_193W_D8

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itpr1^{tm1.1(NCOM)Mfgc} mutation (1 available); any Itpr1 mutation (185 available)

Data Sources

IMPC Data for Itpr1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

small epididymis ( J:211773 )

IMPC - TCP

Allelic Composition	Itpr1^em1Drf/Itpr1⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itpr1^em1Drf mutation (0 available); any Itpr1 mutation (185 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal iris morphology ( J:231957 )

• minor defects in the iris are seen in adult mice (76 days of age), however, no major anomalies are observed

• embryos show no obvious morphological differences in the early development of the iris

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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