Phenotypes associated with this allele

• Allele Symbol: Il5⁺
• Allele Name: wild type
• Allele ID: MGI:2431097
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Il5^tm1Ktk/Il5^+	B6.129S4-Il5^tm1Ktk	MGI:5312103
ht2	Il5^tm1.1(icre)Lky/Il5^+	C57BL/6-Il5^tm1.1(icre)Lky	MGI:5558888
cn3	Gt(ROSA)26Sor^tm1(DTA)Lky/? Il5^tm1.1(icre)Lky/Il5^+ Rag1^tm1Mom/Rag1^tm1Mom	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:5558890

Genotype
MGI:5312103

ht1

• Allelic Composition: Il5^tm1Ktk/Il5⁺
• Genetic Background: B6.129S4-Il5^tm1Ktk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased interleukin-5 secretion ( J:180790 )

• in lung cells treated with IL33

• in Th2 cells treated with PMA and ionomycin or anti-CD3 antibodies

Genotype
MGI:5558888

ht2

• Allelic Composition: Il5^{tm1.1(icre)Lky}/Il5⁺
• Genetic Background: C57BL/6-Il5^{tm1.1(icre)Lky}

homeostasis/metabolism

decreased circulating interleukin-5 level ( J:206097 )

• serum has about half of the normal level of Il5

immune system

decreased circulating interleukin-5 level ( J:206097 )

• serum has about half of the normal level of Il5

Genotype
MGI:5558890

cn3

• Allelic Composition: Gt(ROSA)26Sor^tm1(DTA)Lky/?; Il5^{tm1.1(icre)Lky}/Il5⁺; Rag1^tm1Mom/Rag1^tm1Mom
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

immune system

abnormal immune system physiology ( J:206097 )

• no increase in type 2 innate lymphoid cells (ILC2) or induction of eotaxin-1 (Ccl11) is detected in lungs in response to administration of Il2 and Il33 in contrast to control mice lacking DTA expression which have a higher ILC2 population and Ccl11 expression