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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hmgn1+
wild type
MGI:2431032
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Hmgn1tm1Mbus/Hmgn1+ either: (involves: 129/Sv * 129X1/SvJ) or (involves: 129/Sv * 129X1/SvJ * C57BL/6) MGI:3617364
ht2
 		Hmgn1tm1Mbus/Hmgn1+ involves: 129X1/SvJ MGI:3617363


Genotype
MGI:3617364
ht1
Allelic
Composition		 Hmgn1tm1Mbus/Hmgn1+
Genetic
Background		 either: (involves: 129/Sv * 129X1/SvJ) or (involves: 129/Sv * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgn1tm1Mbus mutation (2 available); any Hmgn1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased cellular sensitivity to ultraviolet irradiation induced cell death ( J:100282 )
• primary MEFs are more sensitive to UV-C irradiation induced death compared to wild-type cells but less sensitive than homozygous cells




Genotype
MGI:3617363
ht2
Allelic
Composition		 Hmgn1tm1Mbus/Hmgn1+
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgn1tm1Mbus mutation (2 available); any Hmgn1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased mortality induced by gamma-irradiation ( J:100773 )
• 1 year after sublethal gamma-irradiation only 49% of heterozygous mice survive compared to 75% of wild-type littermates

cellular
increased cellular sensitivity to gamma-irradiation induced cell death ( J:100773 )
• primary MEFs are more sensitive to gamma-irradiation induced death compared to wild-type cells but less sensitive than homozygous cells

homeostasis/metabolism
increased cellular sensitivity to gamma-irradiation induced cell death ( J:100773 )
• primary MEFs are more sensitive to gamma-irradiation induced death compared to wild-type cells but less sensitive than homozygous cells
increased mortality induced by gamma-irradiation ( J:100773 )
• 1 year after sublethal gamma-irradiation only 49% of heterozygous mice survive compared to 75% of wild-type littermates




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory