All Phenotypes Hoxb8<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxb8⁺
wild type
MGI:2430913

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hoxb8^tm1.1Jdes/Hoxb8⁺	involves: 129P2/OlaHsd * FVB	MGI:3840808
ht2	Hoxb8^tm1Omm/Hoxb8⁺	involves: 129S7/SvEvBrd	MGI:2683140
ht3	Hoxb8^tm1Omm/Hoxb8⁺	involves: 129S7/SvEvBrd * C57BL/6	MGI:2683141

Allelic Composition	Hoxb8^tm1.1Jdes/Hoxb8⁺
Genetic Background	involves: 129P2/OlaHsd * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb8^tm1.1Jdes mutation (0 available); any Hoxb8 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dorsal root ganglion morphology ( J:58621 )

• 4 of 4 mice exhibit abnormal rostral moiety of the left side of the C2 spinal ganglion

• 3 of 4 mice exhibit abnormal rostral moiety of the right side of the C2 spinal ganglion

• mice exhibit degeneration of the C2 spinal ganglion unlike in wild-type mice

• the C2 ganglia is abnormal in shape and position

abnormal spinal nerve morphology ( J:58621 )

• one mouse lacked the venral ramus of the second spinal nerve while it is thinner in other mice compared to in wild-type mice

skeleton

abnormal sternocostal joint morphology ( J:58621 )

• in 6% of mice, rib to sternum attachment points exhibit defects ranging from unilateral inversion of the point of attachment of T1 and T2 to unilateral shifts of the points of attachments of T1 to T5 unlike in wild-type mice

Allelic Composition	Hoxb8^tm1Omm/Hoxb8⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb8^tm1Omm mutation (0 available); any Hoxb8 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

thoracic vertebral transformation ( J:86684 )

• thoracic homeotic transformations: the first thoracic (T1) vertebra develops into the more anterior cervical vertebra C7, and the second thoracic (T2) vertebra develops into T1

• Background Sensitivity: 44% penetrance on a 129S/SvEv genetic background, a higher percentage than on a mixed 129S7/SvEvBrd and C57BL/6 background

Allelic Composition	Hoxb8^tm1Omm/Hoxb8⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb8^tm1Omm mutation (0 available); any Hoxb8 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

thoracic vertebral transformation ( J:86684 )

• thoracic homeotic transformations: the first thoracic (T1) vertebra develops into the more anterior cervical vertebra C7, and the second thoracic (T2) vertebra develops into T1

• Background Sensitivity: 18% penetrance on a mixed genetic background involving 129S/SvEv and C57BL/6, a lower percentage than on a 129S7/SvEvBrd background

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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