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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hoxa5+
wild type
MGI:2430904
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hoxa5tm1.1Ljea/Hoxa5+
Tg(Sftpc-cre)1Blh/0 		involves: 129 * C57BL/6J * DBA/2 * SJL MGI:6404242
cx2
 		Hoxa5tm1Rob/Hoxa5+
Hoxa6tm1Mrc/Hoxa6+
Hoxb5tm1Mrc/Hoxb5+
Hoxb6tm1Mrc/Hoxb6+
Hoxc5tm1Mrc/Hoxc5+
Hoxc6tm1Dds/Hoxc6+ 		involves: 129S/SvEv * 129S7/SvEvBrd MGI:4358354


Genotype
MGI:6404242
cn1
Allelic
Composition		 Hoxa5tm1.1Ljea/Hoxa5+
Tg(Sftpc-cre)1Blh/0
Genetic
Background		 involves: 129 * C57BL/6J * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5tm1.1Ljea mutation (1 available); any Hoxa5 mutation (28 available)
Tg(Sftpc-cre)1Blh mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
lung cyst ( J:170336 )
• as in mice with only Tg(Sftpc-cre)1Blh
abnormal pulmonary alveolar sac morphology ( J:170336 )
• distended alveoli at the periphery of lobes at day 30 as in mice with only Tg(Sftpc-cre)1Blh

growth/size/body
lung cyst ( J:170336 )
• as in mice with only Tg(Sftpc-cre)1Blh




Genotype
MGI:4358354
cx2
Allelic
Composition		 Hoxa5tm1Rob/Hoxa5+
Hoxa6tm1Mrc/Hoxa6+
Hoxb5tm1Mrc/Hoxb5+
Hoxb6tm1Mrc/Hoxb6+
Hoxc5tm1Mrc/Hoxc5+
Hoxc6tm1Dds/Hoxc6+
Genetic
Background		 involves: 129S/SvEv * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa5tm1Rob mutation (1 available); any Hoxa5 mutation (28 available)
Hoxa6tm1Mrc mutation (0 available); any Hoxa6 mutation (9 available)
Hoxb5tm1Mrc mutation (0 available); any Hoxb5 mutation (11 available)
Hoxb6tm1Mrc mutation (0 available); any Hoxb6 mutation (14 available)
Hoxc5tm1Mrc mutation (0 available); any Hoxc5 mutation (11 available)
Hoxc6tm1Dds mutation (0 available); any Hoxc6 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal skeleton morphology ( J:124112 )
• primaxial and abaxial skeleton defects are less severe than in either triple homozygote




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory