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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrp2+
wild type
MGI:2430761
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Lrp2tm1Her/Lrp2+ involves: 129S7/SvEvBrd * C57BL/6 MGI:3790951
ht2
 		Lrp2tm3Tew/Lrp2+ Not Specified MGI:5426263


Genotype
MGI:3790951
ht1
Allelic
Composition		 Lrp2tm1Her/Lrp2+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp2tm1Her mutation (1 available); any Lrp2 mutation (263 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal ear physiology ( J:134797 )
• uptake of FITC-labeled beta-estrogen into the strial marginal cells is reduced
increased or absent threshold for auditory brainstem response ( J:134797 )
• heterozygotes older than 6 months exhibit a moderate, but significant, elevation in click-ABR threshold
impaired hearing ( J:134797 )
• moderate hearing loss is seen at 6 months of age




Genotype
MGI:5426263
ht2
Allelic
Composition		 Lrp2tm3Tew/Lrp2+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp2tm3Tew mutation (0 available); any Lrp2 mutation (263 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:184259 )
N
• no low level protein urea
• no defect in uptake of vitamin D-binding protein
• urinary electrolytes are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory