Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gad1+ wild type MGI:2430731 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• GABA levels in cortex at P0.5 are 65% of wild-type; similar degree of reduction is observed at E14.5
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• glutamic acid decarboxylase activity in cerebral cortex is 62% of wild-type littermates at P0.5; similar reduction is observed at E14.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• basket interneurons display reduction in the number of terminal branches, and the density and size of boutons around pyramidal cell somata (4.2+/-0.2 boutons per soma compared to 9.8+/-0.3 boutons per soma in wild-type mice)basket interneurons display reduction in the number of terminal branches, and the density and size of boutons around pyramidal cell somata (4.2+/-0.2 boutons per soma compared to 9.8+/-0.3 boutons per soma in wild-type mice)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following infection with an andenovirus-cre, the axons of basket interneurons are thinner and have reduced numbers of finer branches especially terminal branches compared to in control cells
• following infection with an andenovirus-cre, terminal branches have fewer and smaller boutons around pyramidal cell somata throughout the innervation field (5.0+/-0.3 boutons per soma compared to 8.9+/-0.4 boutons per soma in control cells)
• however, NO711 treatment following infection with an andenovirus-cre rescues perisomatic bouton formation and increases complexity of ternimal branches, bouton density, and size of perisomatic boutons while treatment with diazepam treated cells show much less pronounced perisomatic synapse defects
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• chorda tympani nerves response to sour tastants is lower than in wild-type mice
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• chorda tympani nerves response to sour tastants is lower than in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• cultured interneurons from brain slices exhibit reduced and slower cell migration to the olfactory bulb compared with wild-type interneurons
• at E13.5, Gad67-GFP+ interneurons in the rostral ventral forebrain exhibit decreased net rate of migration, shorter somal translocation, fewer translocation per hour, longer pauses, and fewer direction changes compared with wild-type interneurons
• at E15.5, migration of dorsal lateral ganglionic eminence-derived interneurons is disrupted compared to in wild-type mice
• at E18.5, cells in the anterior subventricular zone exhibit decreased migration to the olfactory bulb compared with wild-type cells
• mice exhibit ectopic streaks of Gad67(Gad1)-GFP+ interneurons extending radially from the anterior subventricular zone in the rostral cortex unlike in wild-type mice
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• at E14.5 and E17.5, mice exhibit fewer proliferation cells at the ventricular surface and increased proliferating cells at the cortical plate compared with wild-type mice
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• between E10.5 and E15.5, mice exhibit increased apoptosis throughout the brain and body compared with wild-type mice
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• cultured interneurons from brain slices exhibit reduced and slower cell migration to the olfactory bulb compared with wild-type interneurons
• at E13.5, Gad67-GFP+ interneurons in the rostral ventral forebrain exhibit decreased net rate of migration, shorter somal translocation, fewer translocation per hour, longer pauses, and fewer direction changes compared with wild-type interneurons
• at E15.5, migration of dorsal lateral ganglionic eminence-derived interneurons is disrupted compared to in wild-type mice
• at E18.5, cells in the anterior subventricular zone exhibit decreased migration to the olfactory bulb compared with wild-type cells
• mice exhibit ectopic streaks of Gad67(Gad1)-GFP+ interneurons extending radially from the anterior subventricular zone in the rostral cortex unlike in wild-type mice
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• at E14.5 and E17.5, mice exhibit fewer proliferation cells at the ventricular surface and increased proliferating cells at the cortical plate compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most die before 15 weeks of age, especially during pregnancy
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• frequency at birth is lower than at E14
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/30/2025 MGI 6.24 |
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