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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dhfr+
wild type
MGI:2430403
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Dhfrtm1b(EUCOMM)Wtsi/Dhfr+ C57BL/6N-Dhfrtm1b(EUCOMM)Wtsi/Tcp MGI:6262282
ht2
 		Dhfrorana/Dhfr+ involves: C57BL/6JAnu MGI:5906028


Genotype
MGI:6262282
ht1
Allelic
Composition		 Dhfrtm1b(EUCOMM)Wtsi/Dhfr+
Genetic
Background		 C57BL/6N-Dhfrtm1b(EUCOMM)Wtsi/Tcp
Cell Lines EPD0459_2_H07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhfrtm1b(EUCOMM)Wtsi mutation (1 available); any Dhfr mutation (16 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

homeostasis/metabolism

nervous system




Genotype
MGI:5906028
ht2
Allelic
Composition		 Dhfrorana/Dhfr+
Genetic
Background		 involves: C57BL/6JAnu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhfrorana mutation (0 available); any Dhfr mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
enlarged spleen ( J:236197 )
• following exposure to 5-fluorouracil
abnormal hemopoiesis ( J:236197 )
• in untreated mice and following exposure to 5-fluorouracil
extramedullary hematopoiesis ( J:236197 )
• prolonged following exposure to 5-fluorouracil

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:236197 )
N
• mice exhibit normal plasma homocysteine levels
abnormal folic acid level ( J:236197 )
• half as much total folate in the bone marrow as in wild-type mice
• however, sub-species levels are normal

cardiovascular system
decreased vasodilation ( J:236197 )
• impaired endothelium-dependent in the aorta
• however, mice exhibit normal relaxation induced by the NO donor DEANO

immune system
enlarged spleen ( J:236197 )
• following exposure to 5-fluorouracil

muscle
decreased vasodilation ( J:236197 )
• impaired endothelium-dependent in the aorta
• however, mice exhibit normal relaxation induced by the NO donor DEANO

growth/size/body
enlarged spleen ( J:236197 )
• following exposure to 5-fluorouracil




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory