All Phenotypes Ctsl<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ctsl⁺
wild type
MGI:2430334

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ctsl^tm1Alpk/Ctsl⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3584504
ht2	Ctsl^tm1.2Thre/Ctsl⁺	involves: C57BL/6 * C57BL/6N	MGI:5810300
ht3	Ctsl^tm1Cptr/Ctsl⁺	NOD.129P2-Ctsl^tm1Cptr	MGI:4420986

Allelic Composition	Ctsl^tm1Alpk/Ctsl⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsl^tm1Alpk mutation (0 available); any Ctsl mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal trabecular bone morphology ( J:99755 )

• the amount of trabecular bone is significantly reduced; however following ovariectomy the extent of bone loss is reduced in heterozygotes compared to wild-type mice (reduction in bone volume of 36.17% compared to 51.7% in wild-type)

abnormal cartilage morphology ( J:99755 )

• the mineralized cartilage zone is disorganized

integument

focal dorsal hair loss ( J:99755 )

• at 9 months of age, heterozygous females have a bald area covering the central dorsal surface and males have small bald patches

Allelic Composition	Ctsl^tm1.2Thre/Ctsl⁺
Genetic Background	involves: C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsl^tm1.2Thre mutation (0 available); any Ctsl mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:216506 )

N	• at P30, mice exhibit normal coat appearance

Allelic Composition	Ctsl^tm1Cptr/Ctsl⁺
Genetic Background	NOD.129P2-Ctsl^tm1Cptr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsl^tm1Cptr mutation (2 available); any Ctsl mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

insulitis ( J:153355 )

• insulitis scores for diabetic animals are similar to diabetic NOD controls

decreased susceptibility to autoimmune diabetes ( J:153355 )

• 55% of female mice exhibit blood glucose levels of greater than 250 mg/dl between 4-6 months of age as compared to 69% of NOD controls

• adoptive transfer of GITR^hi-depleted Treg cells into NOD-Prkdc^scid host results in a diabetes incidence of 41.7%

homeostasis/metabolism

hyperglycemia ( J:153355 )

• 55% of female mice exhibit blood glucose levels of greater than 250 mg/dl between 4-6 months of age as compared to 69% of NOD controls

endocrine/exocrine glands

insulitis ( J:153355 )

• insulitis scores for diabetic animals are similar to diabetic NOD controls

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