All Phenotypes Csk<+> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Csk⁺
wild type
MGI:2430311

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Csk^tm1Sor/Csk⁺	129P2.129S7-Csk^tm1Sor	MGI:5441315
ht2	Csk^{tm2b(EUCOMM)Hmgu}/Csk⁺	C57BL/6N-Csk^{tm2b(EUCOMM)Hmgu}/Bay	MGI:6370395
ht3	Csk^tm1Sia/Csk⁺	involves: BALB/c * C57BL/6 * CBA	MGI:3655384
cx4	Csk^tm1Sor/Csk⁺ Ptprc^ltng/Ptprc^ltng	involves: 129S7/SvEvBrd * C57BL/6	MGI:4442176
cx5	Csk^tm1Sor/Csk⁺ Ptprc^ltng/Ptprc^tm1Mak	involves: 129S7/SvEvBrd * C57BL/6	MGI:4442178

Allelic Composition	Csk^tm1Sor/Csk⁺
Genetic Background	129P2.129S7-Csk^tm1Sor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csk^tm1Sor mutation (2 available); any Csk mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal object recognition memory ( J:188631 )

• no increased investigation of displaced familiar objects, similar to 129P2 control but unlike C57BL/6 control

abnormal food preference ( J:188631 )

• given a chose of two novel food sources they choose a food they have already seen another mouse eat

decreased anxiety-related response ( J:188631 )

• increased time spent exploring open arms of an elevated + maze

abnormal social investigation ( J:188631 )

• increased social approach of a strange mouse as opposed to investigating an empty cage or examining a pre-exposed familiar mouse

• less time is spent re-investigating a strange mouse during second exposure to that mouse

• given a chose of two novel food sources they choose a food they have already seen another mouse eat

Allelic Composition	Csk^{tm2b(EUCOMM)Hmgu}/Csk⁺
Genetic Background	C57BL/6N-Csk^{tm2b(EUCOMM)Hmgu}/Bay
Cell Lines	HEPD0640_2_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csk^{tm2b(EUCOMM)Hmgu} mutation (0 available); any Csk mutation (25 available)

Data Sources

IMPC Data for Csk

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

IMPC - BCM

homeostasis/metabolism

decreased circulating aspartate transaminase level ( J:211773 )

IMPC - BCM

vision/eye

abnormal retina vasculature morphology ( J:211773 )

IMPC - BCM

abnormal retina inner nuclear layer morphology ( J:211773 )

IMPC - BCM

decreased total retina thickness ( J:211773 )

IMPC - BCM

Allelic Composition	Csk^tm1Sia/Csk⁺
Genetic Background	involves: BALB/c * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csk^tm1Sia mutation (0 available); any Csk mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:12623 )

• heterozygotes are viable and fertile and do not develop spontaneous tumors up to 9 months of age

Allelic Composition	Csk^tm1Sor/Csk⁺ Ptprc^ltng/Ptprc^ltng
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csk^tm1Sor mutation (2 available); any Csk mutation (25 available)
Ptprc^ltng mutation (3 available); any Ptprc mutation (212 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thymus hypoplasia ( J:158876 )

immune system

thymus hypoplasia ( J:158876 )

endocrine/exocrine glands

thymus hypoplasia ( J:158876 )

Allelic Composition	Csk^tm1Sor/Csk⁺ Ptprc^ltng/Ptprc^tm1Mak
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:158876 )

abnormal T cell differentiation ( J:158876 )

• ligand-independent signaling checkpoint in T cell development is rescued compared to in Ptprc^ltng/Ptprc^tm1Mak heterozygotes and comparable to in Ptprc^ltng homozygotes

hematopoietic system

thymus hypoplasia ( J:158876 )

abnormal T cell differentiation ( J:158876 )

• ligand-independent signaling checkpoint in T cell development is rescued compared to in Ptprc^ltng/Ptprc^tm1Mak heterozygotes and comparable to in Ptprc^ltng homozygotes

endocrine/exocrine glands

thymus hypoplasia ( J:158876 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/30/2025 MGI 6.24