Phenotypes associated with this allele

• Allele Symbol: Cryaa⁺
• Allele Name: wild type
• Allele ID: MGI:2430304
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cryaa^Aey7/Cryaa^+	C3HeB/FeJ-Cryaa^Aey7/Ieg	MGI:2653234
ht2	Cryaa^tm1Ady/Cryaa^+	involves: 129	MGI:4437476
ht3	Cryaa^tm1.1Ady/Cryaa^+	involves: 129 * C57BL/6	MGI:3784582
ht4	Cryaa^tm1Wawr/Cryaa^+	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:2681049
ht5	Cryaa^tm1Wawr/Cryaa^+	involves: 129/Sv * 129S4/SvJae	MGI:2681051
ht6	Cryaa^L1N/Cryaa^+	involves: C3H/HeN * C57BL/6J	MGI:3690117

Genotype
MGI:2653234

ht1

• Allelic Composition: Cryaa^Aey7/Cryaa⁺
• Genetic Background: C3HeB/FeJ-Cryaa^Aey7/Ieg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens morphology ( J:72928 )

• clefts apparent in the subcortical zone and nucleus at 7 weeks of age; this region corresponded to regions of developing opacity

cataract ( J:72928 )

• described as progressive, starting as a visible opacity in the embryonic nucleus and resulting in a zonal and nuclear opacity by 2 months of age

microphthalmia ( J:72928 )

• small eyes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 9 multiple types		DOID:0110266	OMIM:604219	J:72928

Genotype
MGI:4437476

ht2

• Allelic Composition: Cryaa^tm1Ady/Cryaa⁺
• Genetic Background: involves: 129

Lens opacity in Cryaa^tm1Ady/Cryaa⁺, Cryaa^tm1Ady/Cryaa^tm1Ady, and Cryaa^tm1.1Ady/Cryaa^tm1.1Ady mice

vision/eye

abnormal lens morphology ( J:157274 )

• at 9 months, mice exhibit severe posterior rupture of the lens, curling up of the posterior capsule, and migration of cells to the posterior lens unlike wild-type mice

ruptured lens capsule ( J:157274 )

• at 9 months, mice exhibit severe posterior rupture of the lens unlike wild-type mice

abnormal lens fiber morphology ( J:157274 )

• at 3 weeks, lenses contain small and large swollen cells or vacuoles in the lens cortical fiber unlike in wild-type mice

cataract ( J:157274 )

• beginning at 2 to 3 months of age and worsening with age in the posterior and nuclear regions of the lens

nuclear cataract ( J:157274 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 9 multiple types		DOID:0110266	OMIM:604219	J:157274

Genotype
MGI:3784582

ht3

• Allelic Composition: Cryaa^tm1.1Ady/Cryaa⁺
• Genetic Background: involves: 129 * C57BL/6

Lens opacity in Cryaa^tm1.1Ady/Cryaa⁺, and Cryaa^tm1.1Ady/Cryaa^tm1.1Ady mice and microphthalmia in Cryaa^tm1.1Ady/Cryaa^tm1.1Ady mice

vision/eye

abnormal lens morphology ( J:132296 )

• increased amounts of alphaA-crystallin and alphaB-crystallin in the lens-insoluble fractions at lesser degree than homozygous mice

cataract ( J:132296 )

• less severe lens opacities in heterozygous mice compared to homozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 9 multiple types		DOID:0110266	OMIM:604219	J:132296

Genotype
MGI:2681049

ht4

• Allelic Composition: Cryaa^tm1Wawr/Cryaa⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

vision/eye

small lens ( J:38210 )

• small lens; 10-15% reduced weight and 5% reduced axial and equatorial dimensions

Genotype
MGI:2681051

ht5

• Allelic Composition: Cryaa^tm1Wawr/Cryaa⁺
• Genetic Background: involves: 129/Sv * 129S4/SvJae

vision/eye

small lens ( J:38210 )

• small lens; 10-15% reduced weight and 5% reduced axial and equatorial dimensions

Genotype
MGI:3690117

ht6

• Allelic Composition: Cryaa^L1N/Cryaa⁺
• Genetic Background: involves: C3H/HeN * C57BL/6J

vision/eye

cataract ( J:112248 )

small lens ( J:112248 )

• at 3 weeks, wet weight of heterozygous lenses is 3.31 mg compared to 3.55 mg in wild-type (19% less)